Effect of early stress on hippocampal gray matter is influenced by a functional polymorphism in EAAT2 in bipolar disorder

Sara Poletti, Clara Locatelli, Daniele Radaelli, Cristina Lorenzi, Enrico Smeraldi, Cristina Colombo, Francesco Benedetti

Research output: Contribution to journalArticlepeer-review

Abstract

Current views on the pathogenesis of psychiatric disorders focus on the interplay between genetic and environmental factors, with individual variation in vulnerability and resilience to hazards being part of the multifactorial development of illness. The aim of the study is to investigate the effect of glutamate transporter polymorphism SLC1A2-181A. >. C and exposure to Adverse Childhood Experiences (ACE) on hippocampal gray matter volume of patients with bipolar disorder (BD).Patients exposed to higher levels of ACE reported lower gray matter volume. The effect of SLC1A2-181A. >. C revealed itself only among patients exposed to lower levels of ACE, with T/T homozygotes showing the lowest, and G/G the highest, gray matter volume.The greatest difference between high and low exposures to ACE was observed in carriers of the G allele. Since the mutant G allele has been associated with a reduced transcriptional activity and expression of the transporter protein, we could hypothesize that after exposure to highest levels of ACE G/G homozygotes are more vulnerable to stress reporting the highest brain damage as a consequence of an excess of free glutamate.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume51
DOIs
Publication statusPublished - Jun 3 2014

Keywords

  • Adverse childhood experiences
  • Bipolar disorder
  • EAAT2
  • Glutamate
  • Hippocampus

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology
  • Medicine(all)

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