Effect of efalizumab on neutrophil and monocyte functions in patients with psoriasis

Franco Capsoni, A. M. Ongari, E. Frigerio, M. Taglioni, G. F. Altomare

Research output: Contribution to journalArticle

Abstract

We evaluated the effect of efalizumab on neutrophil and monocyte functions. The in vitro preincubation with efalizumab concentrations similar to those reached during in vivo therapy almost completely saturated CD11a binding sites without affecting the membrane expression of CD11b, CD128a or CD128b. There was a significant reduction in the chemotactic activity of the pre-treated cells toward three different chemo-attractants, whereas their phagocytic capacity and production of oxygen radicals remained unchanged. One month after the administration of efalizumab to five patients with psoriasis (T1) circulating neutrophil counts increased by 34% from pre-therapy (T0) with no change in the number of monocytes. In the same patients the CD11a binding sites on phagocytes were >90% saturated, and there was also a significant down-modulation on neutrophils (44% of T0) and monocytes (63% of T0). In line with in vitro results, efalizumab treatment caused a significant deficiency in the chemotactic properties of neutrophils and monocytes, but no changes in phagocytosis, oxidative burst, production of pro-inflammatory cytokines or the membrane expression of CD11b, CD128a and CD128b. Our findings suggest that neutrophils and monocytes may be among the targets of efalizumab activity in patients with psoriasis.

Original languageEnglish
Pages (from-to)437-445
Number of pages9
JournalInternational Journal of Immunopathology and Pharmacology
Volume21
Issue number2
Publication statusPublished - Apr 2008

Keywords

  • Chemotactic activity
  • Efalizumab
  • Monocyte
  • Neutrophil
  • Plaque psoriasis

ASJC Scopus subject areas

  • Pharmacology

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    Capsoni, F., Ongari, A. M., Frigerio, E., Taglioni, M., & Altomare, G. F. (2008). Effect of efalizumab on neutrophil and monocyte functions in patients with psoriasis. International Journal of Immunopathology and Pharmacology, 21(2), 437-445.