Effect of electrode distance in electrochemotherapy: From numerical model to in vitro tests

A. Ongaro, L. G. Campana, M. De Mattei, F. Dughiero, M. Forzan, A. Pellati, Elisabetta Sieni, C. R. Rossi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, the electric field generated in a conductive medium by needles pairs with inter-needle distance of 1 or 2 cm has been studied by means of 3D numerical models. The computational results have been correlated with experimental ones obtained in vitro on cultured cells. In particular, electroporation effect has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. These results are helpful to evaluate the effect of the needle distance on the electric field distribution in cultured cells in terms of occurrence of reversible or irreversible electroporation.

Original languageEnglish
Title of host publicationIFMBE Proceedings
PublisherSpringer Verlag
Pages167-170
Number of pages4
Volume53
ISBN (Print)9789812878168
DOIs
Publication statusPublished - 2016
Event1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 - Portoroz, Slovenia
Duration: Sep 6 2015Sep 10 2015

Other

Other1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015
Country/TerritorySlovenia
CityPortoroz
Period9/6/159/10/15

Keywords

  • Electric field
  • Electrode
  • Electroporation
  • Propidium iodide
  • Reversible and irreversible electroporation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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