Thymus derived (T) and bursa equivalent derived (B) lymphocyte functions of AKR and C58 mice, natural carriers of endogenous Gross-MuLV, were compared to those of normal, passage A Gross- and Graffi-MuLV neonatally injected CBA mice. The same percentage of θ positive T lymphocytes was found in blood, spleen and lymph node from normal donors of the three strains. Results of PHA stimulation of spleen cells in vitro disclosed depressed values for the leukemia-prone strains. Moreover, only C58 spleen cell cultures stimulated by LPS were depressed. However, no significant reduction in PHA and LPS in vitro response was observed in spleen cultures from passage A Gross and Graffi-MuLV neonatally injected, leukemia-free CBA mice. Following in vivo immunization with SRBC, AKR mice produced significantly less PFC than both C58 and CBA mice. After immunization with LPS, both AKR and C58 mice produced significantly less PFC than CBA mice. In leukemia-free, passage A Gross- and Graffi-MuLV neonatally injected CBA mice similarly immunized with SRBC and LPS, a slight but significant reduction in the PFC number against SRBC was found only in Graff-MuLV injected mice. The remaining groups gave values similar to their controls.
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