Vliianie épitalona i vilona na prodolzhitel'nost' zhizni i razvitie opukholei molochnoi zhelezy u samok transgennykh mishei erB-2/neu.

Translated title of the contribution: Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice

I. N. Alimova, D. A. Bashurin, I. G. Popovich, M. A. Zabezhinskiǐ, M. A. Volkov, M. Provinciali, C. Franceschi, B. K. Khavincon, V. N. Anisimov

Research output: Contribution to journalArticle

Abstract

Female transgenic FVB mice transfected with the mammary erbB-2/neu oncogene were injected 0.1 ml 0.9% solution of sodium chloride (control), 1 meg Vilon peptide (Lys-Glu) or Epitalon peptide (Ala-Glu-Asp-Glu), s.c., 5 days in succession once a month, beginning from the age of 2 months. The characteristics of mammary tumor induction in the control and experimental groups did not differ until the age of 9 months. Later on, Epitalon-treated mice revealed distinct inhibition of carcinogenesis. One tumor per animal was detected in 7% (control), 4% (Vilon) and 16% (Epitalon) (p <0.05). Two or more tumors per animal were in 75%, 95% and 56%, respectively (p <0.05). Largest diameter of mammary adenocarcinoma in the Epitalon group was smaller than in controls by 33% (p <0.05). Although the number of mice with metastases to the lung in all three groups was practically identical, their incidence in the Vilon group was 2.6 times higher than in Epitalon-treated animals (p <0.05). Largest diameter of metastasis in the Epitalon group was the smallest, too. Our data point to inhibition of mammary carcinogenesis by Epitalon in transgenic erbB-2/neu mice.

Translated title of the contributionEffect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice
Original languageRussian
Pages (from-to)57-60
Number of pages4
JournalVoprosy Onkologii
Volume48
Issue number1
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Alimova, I. N., Bashurin, D. A., Popovich, I. G., Zabezhinskiǐ, M. A., Volkov, M. A., Provinciali, M., Franceschi, C., Khavincon, B. K., & Anisimov, V. N. (2002). Vliianie épitalona i vilona na prodolzhitel'nost' zhizni i razvitie opukholei molochnoi zhelezy u samok transgennykh mishei erB-2/neu. Voprosy Onkologii, 48(1), 57-60.