Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study

Giovanna Russo, Vito Miraglia, Francesca Branciforte, Sofia Maria Rosaria Matarese, Marco Zecca, Gianni Bisogno, Emilia Parodi, Giovanni Amendola, Paola Giordano, Momcilo Jankovic, Annalisa Corti, Margherita Nardi, Piero Farruggia, Laura Battisti, Carlo Baronci, Giovanni Palazzi, Fabio Tucci, Stefania Ceppi, Bruno Nobili, Ugo RamenghiDomenico De Mattia, Lucia Notarangelo

Research output: Contribution to journalArticle

Abstract

Background: The eradication of Helicobacter pylori has been associated with remission of immune thrombocytopenia (ITP) in approximately half of eradicated patients. Data on children are limited to small case series.Procedure: Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for H. pylori infection. Positive patients underwent standard triple therapy with amoxicillin, clarithromycin, and omeprazole. The eradication response was defined as follows: complete response, platelet (PLT) count ≥150-×-109/L; partial response, PLT count of at least 50-×-109/L; no response, PLT count 9/L.Results: Of 244 screened patients, 50 (20%) had H. pylori infection, 37 of which received eradication therapy and completed follow-up. Eradication was successful in 33/37 patients (89%). PLT recovery was demonstrated in 13/33 patients after eradication (39%), whereas spontaneous remission was observed in 17/166 (10%) H. pylori-negative patients (P-

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalPediatric Blood and Cancer
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2011

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Keywords

  • Children
  • Chronic ITP
  • Helicobacter pylori

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Russo, G., Miraglia, V., Branciforte, F., Matarese, S. M. R., Zecca, M., Bisogno, G., Parodi, E., Amendola, G., Giordano, P., Jankovic, M., Corti, A., Nardi, M., Farruggia, P., Battisti, L., Baronci, C., Palazzi, G., Tucci, F., Ceppi, S., Nobili, B., ... Notarangelo, L. (2011). Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study. Pediatric Blood and Cancer, 56(2), 273-278. https://doi.org/10.1002/pbc.22770