Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients

Mariangela Rondanelli, Annalisa Opizzi, Neldo Antoniello, Federica Boschi, Paolo Iadarola, Evasio Pasini, Roberto Aquilani, Francesco Saverio Dioguardi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background & aims: This study assessed the efficacy of supplemented essential amino acids on depressive symptoms, nutrition, muscle function, daily physical activity, and health-related quality of life (HRQoL) of institutionalized elderly patients. Methods: Forty-one patients (58.5% women; mean age 79.8 yrs) with sequelae of coronary artery disease (73%), femoral fracture (34%), were randomly assigned to receive oral essential amino acids 4 gr 2 times a day for 8 weeks or isocaloric placebo. Before randomization and 8 weeks after the protocol started, the following variables were measured: depressive symptoms (Geriatric Depression Scale, GDS), nutritional panel (Mini Nutritional Assessment, MNA; serum albumin and prealbumin levels), muscle strength (Hand Grip, HG), Activity Daily Life (ADL), Quality of Life (SF-36, HRQoL) and amino acid profile. Results: Compared with the placebo group, EAA patients improved nutrition (MNA score 22.6 ± 1.5 post vs 21.8 ± 1.6 pre; p <0. 04, albumin g/dl 4.04 ± 0.35 post vs 3.88 ± 0.3 pre; p <0.01), GDS(score 10.3 ± 1.75 post vs 13.85 ± 3.37 pre; p <0.001), HG (Kg 19.75 ± 1.7 post vs 18.68 ± 1.36 pre; p = 0.001), ADL (p <0.04) and both physical and mental components of SF-36 (p <0.002). Conclusions: Oral supplementation with essential amino acids improved several determinants of quality of life in institutionalized elderly patients, including depressive symptoms, nutrition, muscle function and daily life activity.

Original languageEnglish
Pages (from-to)571-577
Number of pages7
JournalClinical Nutrition
Volume30
Issue number5
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Essential Amino Acids
Quality of Life
Depression
Amino Acids
Hand Strength
Geriatrics
Hand
Placebos
Muscles
Nutrition Assessment
Prealbumin
Femoral Fractures
Muscle Strength
Random Allocation
Serum Albumin
Coronary Artery Disease
Albumins
Exercise

Keywords

  • Amino acid
  • Dietary supplement
  • Elderly
  • Health-related quality of life
  • Muscle strength
  • Nutrition

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients. / Rondanelli, Mariangela; Opizzi, Annalisa; Antoniello, Neldo; Boschi, Federica; Iadarola, Paolo; Pasini, Evasio; Aquilani, Roberto; Dioguardi, Francesco Saverio.

In: Clinical Nutrition, Vol. 30, No. 5, 10.2011, p. 571-577.

Research output: Contribution to journalArticle

Rondanelli, Mariangela ; Opizzi, Annalisa ; Antoniello, Neldo ; Boschi, Federica ; Iadarola, Paolo ; Pasini, Evasio ; Aquilani, Roberto ; Dioguardi, Francesco Saverio. / Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients. In: Clinical Nutrition. 2011 ; Vol. 30, No. 5. pp. 571-577.
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AU - Antoniello, Neldo

AU - Boschi, Federica

AU - Iadarola, Paolo

AU - Pasini, Evasio

AU - Aquilani, Roberto

AU - Dioguardi, Francesco Saverio

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