Effect of Etanercept on insulin sensitivity in nine patients with psoriasis

Maurizio Marra, A. Campanati, R. Testa, C. Sirolla, A. R. Bonfigli, C. Franceschi, F. Marchegiani, A. Offidani

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolic syndrome is associated to chronic low grade inflammation, characterized by increased levels of inflammatory cytokines, such as Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6). In particular, TNF-α causes a decrease in the insulin-stimulated kinases related to the early phases of the insulin cascade, thereby leading to insulin resistance. Etanercept is a human fusion protein used in the treatment of psoriasis and inflammatory arthritis. It blocks inflammatory response by interfering in the binding of TNF-α to its receptors. The aim of this case report study is to verify the effect of Etanercept on insulin sensitivity, lipid profile and inflammatory status in psoriatic patients. Nine psoriatic patients with stable, active, plaque type psoriasis were enrolled and treated with Etanercept for 24 weeks. We found an improvement in the metabolic assessment with a significant reduction of insulin plasma levels. In particular, this treatment allows to maintain their euglycemic state with lower insulin plasma levels, as confirmed by the improved Homeostasis Model Assessment (HOMA) index. We conclude that Etanercept, probably acting on inflammation, improves insulin sensitivity in psoriatic subjects.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume20
Issue number4
Publication statusPublished - Oct 2007

Keywords

  • Etanercept
  • Inflammation
  • Insulin resistance

ASJC Scopus subject areas

  • Pharmacology

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