Effect of fenfluramine on the intestinal absorption of triglycerides

A. Bizzi, E. Veneroni, S. Garattini

Research output: Contribution to journalArticle

Abstract

Fenfluramine decreased plasma triglycerides in fed rats but not in fasted rats. When this compound was administered to rats in a post-absorptive state, a diminution in lymphatic flow and in triglyceride concentration was observed. Moreover, pretreatment with fenfluramine inhibited a rise in plasma and lymph triglycerides, normally found after an olive oil load. No alterations were noted in the flow rate and density of bile. The motility of the small intestine was decreased. These data suggest that the lowering of plasma triglycerides, elicited by fenfluramine, is at least partially due to inhibition of the intestianal absorption of triglycerides.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalEuropean Journal of Pharmacology
Volume23
Issue number2
DOIs
Publication statusPublished - 1973

Keywords

  • Fenfluramine
  • Intestinal absorption
  • Lymph triglycerides
  • Plasma triglycerides

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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