Effect of fibrinogen concentration and platelet count on the inhibitory effect of abciximab and tirofiban

Giulia Renda, Bianca Rocca, Roberto Crocchiolo, Raimondo De Cristofaro, Raffaele Landolfi

Research output: Contribution to journalArticle

Abstract

Glycoprotein (Gp) IIb/IIIa blockers are powerful antithrombotic agents, but display a wide variability of their effect using weight-adjusted dosing. We investigated whether some hemostatic variables affected in vitro platelet inhibition exerted by the antibody abciximab and the peptidomimetic tirofiban. High fibrinogen concentrations reduced platelet inhibition by tirofiban, assessed in whole blood (r = -0.85, n= 10, p <0.01) and in platelet rich plasma (r = -0.89, n = 10, p <0.01) through PFA 100 and Born's aggregometry assay, respectively. Both drugs were unaffected by von Willebrand factor levels, while platelet count was inversely related to their inhibitory effect (tirofiban: r = -0.9, n = 7, p

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalThrombosis and Haemostasis
Volume89
Issue number2
Publication statusPublished - Feb 1 2003

Keywords

  • Fibrinogen
  • GpIIb-IIIa blockers
  • Inhibition
  • Platelet
  • Receptor occupancy

ASJC Scopus subject areas

  • Hematology

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