Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart

N. Ferrara, P. Abete, D. Leosco, P. Caccese, M. Orlando, P. Landino, S. Sederino, C. Tedeschi, F. Rengo

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Abstract

Flecainide acetate is a new antiarrhythmic drug which suppresses different kinds of experimental arrhythmias. We studied the efficacy of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart by monitoring heart rate, coronary flow rate, left ventricular systolic pressure, dp/dt(max), and the voltage of the epicardial electrogram. Seventy-five male rats were randomized into 5 groups. In group I, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion and then perfused. In group II, flecainide acetate (10-6 M) was given after stabilization and before ischaemic perfusion. In group III, barium chloride (10-3 M) was given after stabilization. In group IV, flecainide acetate was given after stabilization and before barium chloride administration. In group V, acetylcholine chloride (10-6 M) was given after stabilization and before barium chloride administration. In group I, we noted during ischemia a reduction in heart rate, coronary flow rate, left ventricular systolic pressure and dp/dt(max) and an increase in the voltage of the epicardial electrogram. In group II, after administration of flecainide acetate, we observed a reduction in heart rate, left ventricular systolic pressure and dp/dt(max); during the ischaemic period there was no difference in these parameters with respect to group I. Reperfusion induced ventricular arrhythmias in 12 out of 15 hearts in group I and in only 3 out of 15 in group II (p

Original languageEnglish
Pages (from-to)104-114
Number of pages11
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume308
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmacology

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