Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart

N. Ferrara, P. Abete, D. Leosco, P. Caccese, M. Orlando, P. Landino, S. Sederino, C. Tedeschi, F. Rengo

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Abstract

Flecainide acetate is a new antiarrhythmic drug which suppresses different kinds of experimental arrhythmias. We studied the efficacy of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart by monitoring heart rate, coronary flow rate, left ventricular systolic pressure, dp/dt(max), and the voltage of the epicardial electrogram. Seventy-five male rats were randomized into 5 groups. In group I, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion and then perfused. In group II, flecainide acetate (10-6 M) was given after stabilization and before ischaemic perfusion. In group III, barium chloride (10-3 M) was given after stabilization. In group IV, flecainide acetate was given after stabilization and before barium chloride administration. In group V, acetylcholine chloride (10-6 M) was given after stabilization and before barium chloride administration. In group I, we noted during ischemia a reduction in heart rate, coronary flow rate, left ventricular systolic pressure and dp/dt(max) and an increase in the voltage of the epicardial electrogram. In group II, after administration of flecainide acetate, we observed a reduction in heart rate, left ventricular systolic pressure and dp/dt(max); during the ischaemic period there was no difference in these parameters with respect to group I. Reperfusion induced ventricular arrhythmias in 12 out of 15 hearts in group I and in only 3 out of 15 in group II (p

Original languageEnglish
Pages (from-to)104-114
Number of pages11
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume308
Publication statusPublished - 1990

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Flecainide
Barium
Tachycardia
Reperfusion
Ventricular Pressure
Heart Rate
Blood Pressure
Cardiac Arrhythmias
Perfusion
Anti-Arrhythmia Agents
Acetylcholine
Ischemia
barium chloride

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart. / Ferrara, N.; Abete, P.; Leosco, D.; Caccese, P.; Orlando, M.; Landino, P.; Sederino, S.; Tedeschi, C.; Rengo, F.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 308, 1990, p. 104-114.

Research output: Contribution to journalArticle

Ferrara, N, Abete, P, Leosco, D, Caccese, P, Orlando, M, Landino, P, Sederino, S, Tedeschi, C & Rengo, F 1990, 'Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart', Archives Internationales de Pharmacodynamie et de Therapie, vol. 308, pp. 104-114.
Ferrara, N. ; Abete, P. ; Leosco, D. ; Caccese, P. ; Orlando, M. ; Landino, P. ; Sederino, S. ; Tedeschi, C. ; Rengo, F. / Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart. In: Archives Internationales de Pharmacodynamie et de Therapie. 1990 ; Vol. 308. pp. 104-114.
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AU - Sederino, S.

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