Abstract
Flecainide acetate is a new antiarrhythmic drug which suppresses different kinds of experimental arrhythmias. We studied the efficacy of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart by monitoring heart rate, coronary flow rate, left ventricular systolic pressure, dp/dt(max), and the voltage of the epicardial electrogram. Seventy-five male rats were randomized into 5 groups. In group I, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion and then perfused. In group II, flecainide acetate (10-6 M) was given after stabilization and before ischaemic perfusion. In group III, barium chloride (10-3 M) was given after stabilization. In group IV, flecainide acetate was given after stabilization and before barium chloride administration. In group V, acetylcholine chloride (10-6 M) was given after stabilization and before barium chloride administration. In group I, we noted during ischemia a reduction in heart rate, coronary flow rate, left ventricular systolic pressure and dp/dt(max) and an increase in the voltage of the epicardial electrogram. In group II, after administration of flecainide acetate, we observed a reduction in heart rate, left ventricular systolic pressure and dp/dt(max); during the ischaemic period there was no difference in these parameters with respect to group I. Reperfusion induced ventricular arrhythmias in 12 out of 15 hearts in group I and in only 3 out of 15 in group II (p
| Original language | English |
|---|---|
| Pages (from-to) | 104-114 |
| Number of pages | 11 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 308 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart. / Ferrara, N.; Abete, P.; Leosco, D.; Caccese, P.; Orlando, M.; Landino, P.; Sederino, S.; Tedeschi, C.; Rengo, F.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 308, 1990, p. 104-114.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart
AU - Ferrara, N.
AU - Abete, P.
AU - Leosco, D.
AU - Caccese, P.
AU - Orlando, M.
AU - Landino, P.
AU - Sederino, S.
AU - Tedeschi, C.
AU - Rengo, F.
PY - 1990
Y1 - 1990
N2 - Flecainide acetate is a new antiarrhythmic drug which suppresses different kinds of experimental arrhythmias. We studied the efficacy of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart by monitoring heart rate, coronary flow rate, left ventricular systolic pressure, dp/dt(max), and the voltage of the epicardial electrogram. Seventy-five male rats were randomized into 5 groups. In group I, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion and then perfused. In group II, flecainide acetate (10-6 M) was given after stabilization and before ischaemic perfusion. In group III, barium chloride (10-3 M) was given after stabilization. In group IV, flecainide acetate was given after stabilization and before barium chloride administration. In group V, acetylcholine chloride (10-6 M) was given after stabilization and before barium chloride administration. In group I, we noted during ischemia a reduction in heart rate, coronary flow rate, left ventricular systolic pressure and dp/dt(max) and an increase in the voltage of the epicardial electrogram. In group II, after administration of flecainide acetate, we observed a reduction in heart rate, left ventricular systolic pressure and dp/dt(max); during the ischaemic period there was no difference in these parameters with respect to group I. Reperfusion induced ventricular arrhythmias in 12 out of 15 hearts in group I and in only 3 out of 15 in group II (p
AB - Flecainide acetate is a new antiarrhythmic drug which suppresses different kinds of experimental arrhythmias. We studied the efficacy of flecainide acetate on reperfusion- and barium-induced ventricular tachyarrhythmias in the isolated perfused rat heart by monitoring heart rate, coronary flow rate, left ventricular systolic pressure, dp/dt(max), and the voltage of the epicardial electrogram. Seventy-five male rats were randomized into 5 groups. In group I, after a 15 min period of stabilization, hearts were perfused by ischemic perfusion and then perfused. In group II, flecainide acetate (10-6 M) was given after stabilization and before ischaemic perfusion. In group III, barium chloride (10-3 M) was given after stabilization. In group IV, flecainide acetate was given after stabilization and before barium chloride administration. In group V, acetylcholine chloride (10-6 M) was given after stabilization and before barium chloride administration. In group I, we noted during ischemia a reduction in heart rate, coronary flow rate, left ventricular systolic pressure and dp/dt(max) and an increase in the voltage of the epicardial electrogram. In group II, after administration of flecainide acetate, we observed a reduction in heart rate, left ventricular systolic pressure and dp/dt(max); during the ischaemic period there was no difference in these parameters with respect to group I. Reperfusion induced ventricular arrhythmias in 12 out of 15 hearts in group I and in only 3 out of 15 in group II (p
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UR - http://www.scopus.com/inward/citedby.url?scp=0025650686&partnerID=8YFLogxK
M3 - Article
C2 - 2129150
AN - SCOPUS:0025650686
VL - 308
SP - 104
EP - 114
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
ER -