Effetti della carenza di GH/IGF-I sul turnover osseo e collagene in bambini ed adulti con deficit di GH.

Translated title of the contribution: Effect of GH/IGF-I deficiency on bone and collagen turnover in children and adults with GH deficiency

A. Sartorio, A. Conti, M. Monzani, S. Ferrero, O. Biella, G. Casati, G. Faglia

Research output: Contribution to journalArticle

Abstract

Serum bone Gla protein (BGP), marker of osteoblastic function, carboxyterminal cross-linked telopeptide of type I collagen (ICTP), index of bone resorption, and aminoterminal propeptide of type III procollagen, marker of collagen synthesis, were evaluated in children with GH deficiency (GHD), in adults with childhood-onset GHD and in adults with acquired GHD in adultlife. In children with GHD, serum BGP (12.7 +/- 0.5 ng/ml), ICTP (8.5 +/- 0.9 ng/ml) and PIIINP (3.4 +/- 0.4 ng/ml) were significantly lower (p <0.0001, p <0.0001 and p <0.001, respectively) than those observed in a sex and age matched control group (BGP:18.9 +/- 0.9 ng/ml, ICTP: 14.4 +/- 0.6 ng/ml, PIIINP: 6.7 +/- 0.7 ng/ml). In adults with childhood onsed GHD, BGP levels (3.7 +/- 0.4 ng/ml) were significantly lower (p <0.0001) than those recorded in a sex and age matched control group (5.4 +/- 0.1 ng/ml), while ICTP (4.7 +/- 0.7 ng/ml) and PIIINP (3.7 +/- 0.5 ng/ml) levels were similar to those found in controls (ICTP: 4.1 +/- 0.3 ng/ml; PIIINP: 3.3 +/- 0.2 ng/ml). In adults with acquired GHD, serum BGP (5.3 +/- 0.4 ng/ml), ICTP (3.8 +/- 0.4 ng/ml) and PIIINP (3.6 +/- 0.3 ng/ml) levels were not significantly different from those recorded in controls (BGP: 5.4 +/- 0.1 ng/ml, ICTP: 4.1 +/- 0.3 ng/ml, PIIINP: 3.3 +/- 0.2 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

Translated title of the contributionEffect of GH/IGF-I deficiency on bone and collagen turnover in children and adults with GH deficiency
Original languageItalian
Pages (from-to)135-140
Number of pages6
JournalMinerva Endocrinologica
Volume20
Issue number2
Publication statusPublished - Jun 1995

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    Sartorio, A., Conti, A., Monzani, M., Ferrero, S., Biella, O., Casati, G., & Faglia, G. (1995). Effetti della carenza di GH/IGF-I sul turnover osseo e collagene in bambini ed adulti con deficit di GH. Minerva Endocrinologica, 20(2), 135-140.