Effect of gluten-free diet on splenic hypofunction of adult coeliac disease

G. R. Corazza, M. Frisoni, D. Vaira, G. Gasbarrini

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Abstract

Splenic function has been serially measured by counting pitted red cells in 15 coeliac patients, before and during a gluten-free diet. The basal percentage values of pitted cells decreased significantly during treatment but no correlation was observed between the duration of the gluten-free diet and the percentage of recovery of splenic function over basal values. Out of six coeliacs with pitted cells values consistent with splenic hypofunction, three showed a total recovery after gluten withdrawal. Our data suggest that, contrary to recent reports, hyposplenism in adult coeliac disease is improved by a gluten-free diet, and that environmental factors may be important in determining and maintaining this complication.

Original languageEnglish
Pages (from-to)228-230
Number of pages3
JournalGut
Volume24
Issue number3
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Corazza, G. R., Frisoni, M., Vaira, D., & Gasbarrini, G. (1983). Effect of gluten-free diet on splenic hypofunction of adult coeliac disease. Gut, 24(3), 228-230.