Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets

Fabiola Sinigaglia, Antonella Bisio, Mauro Torti, Carlo L. Balduini, Giampiera Bertolino, Cesare Balduini

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex)on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume154
Issue number1
DOIs
Publication statusPublished - Jul 15 1988

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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