TY - JOUR
T1 - Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets
AU - Sinigaglia, Fabiola
AU - Bisio, Antonella
AU - Torti, Mauro
AU - Balduini, Carlo L.
AU - Bertolino, Giampiera
AU - Balduini, Cesare
PY - 1988/7/15
Y1 - 1988/7/15
N2 - We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex)on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.
AB - We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex)on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.
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U2 - 10.1016/0006-291X(88)90678-X
DO - 10.1016/0006-291X(88)90678-X
M3 - Article
C2 - 3395329
AN - SCOPUS:0023793141
VL - 154
SP - 258
EP - 264
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -