Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets

Fabiola Sinigaglia; Antonella Bisio; Mauro Torti; Carlo L. Balduini; Giampiera Bertolino; Cesare Balduini

doi:10.1016/0006-291X(88)90678-X

Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets

Fabiola Sinigaglia, Antonella Bisio, Mauro Torti, Carlo L. Balduini, Giampiera Bertolino, Cesare Balduini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex)on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca²⁺ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca²⁺ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.

Original language	English
Pages (from-to)	258-264
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	154
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(88)90678-X
Publication status	Published - Jul 15 1988

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ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Sinigaglia, F., Bisio, A., Torti, M., Balduini, C. L., Bertolino, G., & Balduini, C. (1988). Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets. Biochemical and Biophysical Research Communications, 154(1), 258-264. https://doi.org/10.1016/0006-291X(88)90678-X

Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets. / Sinigaglia, Fabiola; Bisio, Antonella; Torti, Mauro; Balduini, Carlo L.; Bertolino, Giampiera ; Balduini, Cesare.

In: Biochemical and Biophysical Research Communications, Vol. 154, No. 1, 15.07.1988, p. 258-264.

Research output: Contribution to journal › Article

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10.1016/0006-291X(88)90678-X