Effect of granulocyte colony-stimulating factor on secretion of prolactin, growth hormone, thyroid-stimulating hormone, and cortisol in humans

Tommaso Barreca, Marco Gobbi, Roberto Franceschini, Giovanni Berisso, Emanuela Vallebella, Giovanni Corsini, Angelo Cataldi, Ermanno Rolandi

Research output: Contribution to journalArticle

Abstract

In order to assess the endocrine effects of acute and short-term granulocyte colony-stimulating factor (G-CSF), we studied seven patients with myelo- and lymphoproliferative disorders who were given G-CSF to prevent chemotherapy-induced neutropenia. On day 0, the patients received a placebo; on days 1 to 4, they received recombinant human G-CSF (300 μg, subcutaneously). Plasma prolactin, growth hormone, thyroid-stimulating hormone, and cortisol levels were determined at baseline and hourly for 8 hours on days 0 and 1. Additional blood samples were collected at 12 hours on days 0 and 1, and at 9:00 AM on days 2 to 5 of the study. After administration of G-CSF, no significant variations in circulating hormone levels were observed with respect to baseline and corresponding placebo levels. The data indicate that short-term G-CSF administration does not cause endocrine abnormalities in patients undergoing this cytokine treatment.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalCurrent Therapeutic Research
Volume58
Issue number2
DOIs
Publication statusPublished - 1997

Keywords

  • cortisol
  • granulocyte colony-stimulating factor
  • growth hormone
  • prolactin
  • thyroid-stimulating hormone

ASJC Scopus subject areas

  • Medicine(all)

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