Effect of granulocyte-macrophage colony-stimulating factor on growth of a xenotransplanted human ovarian cancer cell line IGROV-1 in nude mice

E. Noviello, A. Cosimi, G. L. Casartelli, G. Melioli, G. Taverniti, S. Parodi, V. Pistoia, M. Venturini, P. Russo

Research output: Contribution to journalArticlepeer-review

Abstract

The clonal growth of cell lines derived from human ovarian tumours can be stimulated by GM-CSF in vitro. Among these cell lines one of the most responsive is the IGROV-1 cell line. This report describes the influence of GM-CSF on the in vivo growth of IGROV-1 cell xenografts in nude mide. Beginning one day after transplantation of the tumour, the cytokine was administered daily for 31 consecutive days as i.m. injections distant from the tumour lesion at doses of 0.1 μg/kg and 1 μg/kg. CM-CSF caused no significant effects on the growth modulation of the ovarian cancer cells in vivo.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalIn Vivo
Volume8
Issue number2
Publication statusPublished - 1994

Keywords

  • GM-CSF
  • IGROV-1
  • nude mice

ASJC Scopus subject areas

  • Medicine(all)

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