The clonal growth of cell lines derived from human ovarian tumours can be stimulated by GM-CSF in vitro. Among these cell lines one of the most responsive is the IGROV-1 cell line. This report describes the influence of GM-CSF on the in vivo growth of IGROV-1 cell xenografts in nude mide. Beginning one day after transplantation of the tumour, the cytokine was administered daily for 31 consecutive days as i.m. injections distant from the tumour lesion at doses of 0.1 μg/kg and 1 μg/kg. CM-CSF caused no significant effects on the growth modulation of the ovarian cancer cells in vivo.
|Number of pages||8|
|Publication status||Published - 1994|
- nude mice
ASJC Scopus subject areas