Effect of granulocyte-macrophage colony-stimulating factor on prevention of mucositis in head and neck cancer patients treated with chemo-radiotherapy

M. Rosso, G. Blasi, E. Gherlone, R. Rosso

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-nine previously untreated patients with squamous cell carcinoma of the oral cavity and pharynx underwent a treatment program with four courses of chemotherapy alternated with' three courses of radiotherapy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was administered at a dose of 5 μg/mg subcutaneously on the same day as radiation treatment in order to prevent mucositis. No grade 4 mucositis was reported; only four episodes of grade 2 mucositis and thirteen grade 2. Comparing these results with historical patients treated with the same chemotherapy-radiation program but without GM-CSF, the Authors concluded that GM-CSF is an effective treatment for preventing mucositis produced by chemotherapeutic and/or radiotherapeutic interventions in patients at high risk of oropharyngeal mucosal damage.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalJournal of Chemotherapy
Volume9
Issue number5
Publication statusPublished - 1997

Keywords

  • Granulocyte-macrophage colony-stimulating factor
  • Mucositis
  • Oropharyngeal damage
  • Radiation toxicity

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

Fingerprint

Dive into the research topics of 'Effect of granulocyte-macrophage colony-stimulating factor on prevention of mucositis in head and neck cancer patients treated with chemo-radiotherapy'. Together they form a unique fingerprint.

Cite this