Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test

Cristina Solomon, Niels Rahe-Meyer, Herbert Schöchl, Marco Ranucci, Klaus Görlinger

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Point-of-care thromboelastometry (ROTEM®) can be used to assess coagulation in whole blood. In the ROTEM® FIBTEM test, cytochalasin D eliminates the contribution of platelets to the whole blood clot; hence, only the remaining elements, including fibrinogen/fibrin, red blood cells and factor XIII, contribute to clot strength. We investigated the relationships between FIBTEM maximum clot firmness (MCF), whole blood fibrinogen concentration and plasma fibrinogen concentration to determine the impact of haematocrit on these parameters during cardiac surgery. Materials and methods. The relationships between FIBTEM MCF and both whole blood fibrinogen concentration and plasma fibrinogen concentration (Clauss assay) were evaluated pre-operatively and after cardiopulmonary bypass/protamine administration in haematocrit-based subgroups. Results. The study included 157 patients. The correlation coefficient rho between FIBTEM MCF and plasma fibrinogen concentration was 0.68 at baseline and 0.70 after protamine, while that between FIBTEM MCF and whole blood fibrinogen concentration was 0.74 at baseline and 0.72 after protamine (all P

Original languageEnglish
Pages (from-to)412-418
Number of pages7
JournalBlood Transfusion
Volume11
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Cardiac surgery
  • Fibrinogen
  • FIBTEM
  • Haematocrit
  • Thromboelastometry

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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