Effect of HCG therapy on growth rate and biological growth parameters in adolescent with thalassemia major

A. Valtorta, A. Moretta, I. Biscaldi, M. R. Romano, P. Cecchi, A. Gasparoni

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of a long-term HCG therapy on the linear growth and biological growth parameters was studied in 6 thalassemic boys, aged 14.5-15.5 years, with hypogonadotropic hypogonadism. HCG treatment significantly increased growth rate (from 3.3 ± 0.3 to 7.6 ± 0.6 cm/yr; p <0.025) and growth hormone (GH) response to L-DOPA administration (from 12.09 ± 3.3 to 25.4 ± 3.2 ng/ml; p <0.025). Moreover, GH-releasing hormone (GHRH) response to L-DOPA significantly (p <0.05) increased (from 9.2 ± 5.6 to 20.2 ± 6.2 pg/ml) after HCG therapy, but remained significantly (p <0.001) lower than in normal prepuberal-age-matched children (97 ± 20 pg/ml). Our data suggest an impaired GHRH release in thalassemia major.

Original languageEnglish
Pages (from-to)76-77
Number of pages2
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume8
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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