Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients

Paolo Palange, Gabriele Valli, Paolo Onorati, Rosa Antonucci, Patrizia Paoletti, Alessia Rosato, Felice Manfredi, Pietro Serra

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

We tested the hypothesis that heliox breathing, by reducing lung dynamic hyperinflation (DH) and dyspnea (Dys) sensation, may significantly improve exercise endurance capacity in patients with chronic obstructive pulmonary disease [n = 12, forced expiratory volume in 1 s = 1.15 (SD 0.32) liters]. Each subject underwent two cycle ergometer high-intensity constant work rate exercises to exhaustion, one on room air and one on heliox (79% Re-21% O 2). Minute ventilation (V̇E), carbon dioxide output, heart rate, inspiratory capacity (IC), Dys, and arterial partial pressure of CO2 were measured. Exercise endurance time increased significantly with heliox [9.0 (SD 4.5) vs. 4.2 (SD 2.0) min; P <0.001]. This was associated with a significant reduction in lung DH at isotime (Iso), as reflected by the increase in IC [1.97 (SD 0.40) vs. 1.77 (SD 0.41) liters; P <0.001] and a decrease in Dys [6 (SD 1) vs. 8 (SD 1) score; P <0.001]. Heliox induced a state of relative hyperventilation, as reflected by the increase in V̇E [38.3 (SD 7.7) vs. 35.5 (SD 8.8) l/min; P <0.01] and V̇E/carbon dioxide output [36.3 (SD 6.0) vs. 33.9 (SD 5.6); P <0.01] at peak exercise and by the reduction in arterial partial pressure of CO2 at Iso [44 (SD 6) vs. 48 (SD 6) Torr; P <0.05] and at peak exercise [46 (SD 6) vs. 48 (SD 6) Torr; P <0.05]. The reduction in Dys at Iso correlated significantly (R = -0.75; P <0.01) with the increase in IC induced by heliox. The increment induced by heliox in exercise endurance time correlated significantly with resting increment in resting forced expiratory in 1 s (R = 0.88; P <0.01), increase in IC at Iso (R = 0.70; P <0.02), and reduction in Dys at Iso (R = -0.71; P <0.01). In chronic obstructive pulmonary disease, heliox breathing improves high-intensity exercise endurance capacity by increasing maximal ventilatory capacity and by reducing lung DH and Dys.

Original languageEnglish
Pages (from-to)1637-1642
Number of pages6
JournalJournal of Applied Physiology
Volume97
Issue number5
DOIs
Publication statusPublished - Nov 2004

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Dyspnea
Chronic Obstructive Pulmonary Disease
Inspiratory Capacity
Exercise
Lung
Ventilation
Partial Pressure
Carbon Dioxide
Arterial Pressure
Respiration
Lung Volume Measurements
Hyperventilation
Forced Expiratory Volume
heliox
Heart Rate
Air

Keywords

  • Chronic obstructive pulmonary disease
  • Therapy

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Palange, P., Valli, G., Onorati, P., Antonucci, R., Paoletti, P., Rosato, A., ... Serra, P. (2004). Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. Journal of Applied Physiology, 97(5), 1637-1642. https://doi.org/10.1152/japplphysiol.01207.2003

Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. / Palange, Paolo; Valli, Gabriele; Onorati, Paolo; Antonucci, Rosa; Paoletti, Patrizia; Rosato, Alessia; Manfredi, Felice; Serra, Pietro.

In: Journal of Applied Physiology, Vol. 97, No. 5, 11.2004, p. 1637-1642.

Research output: Contribution to journalArticle

Palange, P, Valli, G, Onorati, P, Antonucci, R, Paoletti, P, Rosato, A, Manfredi, F & Serra, P 2004, 'Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients', Journal of Applied Physiology, vol. 97, no. 5, pp. 1637-1642. https://doi.org/10.1152/japplphysiol.01207.2003
Palange, Paolo ; Valli, Gabriele ; Onorati, Paolo ; Antonucci, Rosa ; Paoletti, Patrizia ; Rosato, Alessia ; Manfredi, Felice ; Serra, Pietro. / Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. In: Journal of Applied Physiology. 2004 ; Vol. 97, No. 5. pp. 1637-1642.
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