Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina

G. G. Neri Serneri, G. F. Gensini, L. Poggesi, F. Trotta, P. A. Modesti, M. Boddi, A. Ieri, M. Margheri, G. C. Casolo, M. Bini, C. Rostagno, M. Carnovali, R. Abbate

Research output: Contribution to journalArticlepeer-review

Abstract

399 out of 474 inpatients with unstable angina were monitored for 48 h and 97 of these were found to be refractory to conventional antianginal treatments and entered a randomised double-blind study. With the initial protocol heparin infusion or bolus were compared with aspirin; with a modified protocol, heparin infusion, the best of these three treatments, was compared with alteplase. Patients were monitored for 3 days after starting treatment and then observed clinically for 4 more days. On the first days of treatment heparin infusion significantly decreased the frequency of angina (by 84-94%), episodes of silent ischaemia (by 71-77%), and the overall duration of ischaemia (by 81-86%). Heparin bolus and aspirin were not effective. Alteplase caused small (non-significant) reductions on the first day only. Only minor bleeding complications occurred.

Original languageEnglish
Pages (from-to)615-618
Number of pages4
JournalLancet
Volume335
Issue number8690
DOIs
Publication statusPublished - Mar 17 1990

ASJC Scopus subject areas

  • Medicine(all)

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