Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects

A multi-centre study and systematic review

N. Goossens, C. de Vito, A. Mangia, S. Clément, G. Cenderello, F. Barrera, R. D'Ambrosio, N. Coppola, R. Zampino, M. Stanzione, L. E. Adinolfi, H. Wedemeyer, N. Semmo, B. Müllhaupt, D. Semela, R. Malinverni, D. Moradpour, M. Heim, G. Trincucci, L. Rubbia-Brandt & 1 others F. Negro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV-HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV-HCV and the HCV groups (33% vs 45%, P = .11). In subgroup analysis, lean HBV-HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15% vs 45%, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5% was similar in HBV-HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95% CI 0.53-1.6) although there was significant heterogeneity (I2 69%, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV-HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV-induced steatogenesis by HBV in certain subgroups of patients.

Original languageEnglish
Pages (from-to)920-929
JournalJournal of Viral Hepatitis
Volume25
Issue number8
DOIs
Publication statusPublished - 2018

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Hepatitis B virus
Hepacivirus
Chronic Hepatitis C
Virus Diseases
Viremia
Coinfection

Keywords

  • Hepatitis C virus
  • Hepatitis C-hepatitis B coinfection
  • Metabolic syndrome
  • Steatosis

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

Cite this

Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects : A multi-centre study and systematic review. / Goossens, N.; de Vito, C.; Mangia, A.; Clément, S.; Cenderello, G.; Barrera, F.; D'Ambrosio, R.; Coppola, N.; Zampino, R.; Stanzione, M.; Adinolfi, L. E.; Wedemeyer, H.; Semmo, N.; Müllhaupt, B.; Semela, D.; Malinverni, R.; Moradpour, D.; Heim, M.; Trincucci, G.; Rubbia-Brandt, L.; Negro, F.

In: Journal of Viral Hepatitis, Vol. 25, No. 8, 2018, p. 920-929.

Research output: Contribution to journalArticle

Goossens, N, de Vito, C, Mangia, A, Clément, S, Cenderello, G, Barrera, F, D'Ambrosio, R, Coppola, N, Zampino, R, Stanzione, M, Adinolfi, LE, Wedemeyer, H, Semmo, N, Müllhaupt, B, Semela, D, Malinverni, R, Moradpour, D, Heim, M, Trincucci, G, Rubbia-Brandt, L & Negro, F 2018, 'Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review', Journal of Viral Hepatitis, vol. 25, no. 8, pp. 920-929. https://doi.org/10.1111/jvh.12891
Goossens, N. ; de Vito, C. ; Mangia, A. ; Clément, S. ; Cenderello, G. ; Barrera, F. ; D'Ambrosio, R. ; Coppola, N. ; Zampino, R. ; Stanzione, M. ; Adinolfi, L. E. ; Wedemeyer, H. ; Semmo, N. ; Müllhaupt, B. ; Semela, D. ; Malinverni, R. ; Moradpour, D. ; Heim, M. ; Trincucci, G. ; Rubbia-Brandt, L. ; Negro, F. / Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects : A multi-centre study and systematic review. In: Journal of Viral Hepatitis. 2018 ; Vol. 25, No. 8. pp. 920-929.
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abstract = "It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV-HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV-HCV and the HCV groups (33{\%} vs 45{\%}, P = .11). In subgroup analysis, lean HBV-HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15{\%} vs 45{\%}, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5{\%} was similar in HBV-HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95{\%} CI 0.53-1.6) although there was significant heterogeneity (I2 69{\%}, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV-HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV-induced steatogenesis by HBV in certain subgroups of patients.",
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AU - Clément, S.

AU - Cenderello, G.

AU - Barrera, F.

AU - D'Ambrosio, R.

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AU - Semela, D.

AU - Malinverni, R.

AU - Moradpour, D.

AU - Heim, M.

AU - Trincucci, G.

AU - Rubbia-Brandt, L.

AU - Negro, F.

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N2 - It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls. In the clinical cohort, we included 85 HBV-HCV, 69 HBV and 112 HCV subjects from 16 international centres. There was no significant difference in steatosis prevalence between the HBV-HCV and the HCV groups (33% vs 45%, P = .11). In subgroup analysis, lean HBV-HCV subjects with detectable HBV DNA had less steatosis than lean HCV subjects matched for HCV viremia (15% vs 45%, P = .02). Our literature search identified 5 additional studies included in a systematic review. Overall, prevalence of steatosis > 5% was similar in HBV-HCV infection compared to HCV (pooled odds ratio [OR] 0.91, 95% CI 0.53-1.6) although there was significant heterogeneity (I2 69%, P = .007). In conclusion, although the prevalence of steatosis is similar in HBV-HCV compared to HCV subjects, our analysis suggests that there may be an inhibitory effect of HCV-induced steatogenesis by HBV in certain subgroups of patients.

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