TY - JOUR
T1 - Effect of hexarelin on growth hormone secretion in Down syndrome
AU - Ragusa, Letizia
AU - Alberti, Antonino
AU - Romano, Corrado
AU - Valetto, Maria Rosa
AU - Aimaretti, Gianluca
AU - Proto, Caterina
AU - Imbimbo, Bruno P.
AU - Deghenghi, Romano
AU - Colabucci, Fabio
AU - Ghigo, Ezio
PY - 1996
Y1 - 1996
N2 - We studied the effect of the maximum response dose of hexarelin (HEX), a potent GH-releasing peptide (His-D,2,methyl,Trp-Ala-Trp-D,Phe-Lys-NH2) (HEX, 2 μg/kg i.v. at 0 min), comparing it with that of GHRH (2 μg/kg i.v. at 0 min) in 15 children with Down syndrome (DS, 10 M and 5 F, 7.5-15 years) and in 15 normal short children (NC, 9 M and 6 F, 8.2-15.5 years). Basal IGF-I levels were similar in DS and NC (313.85 ± 41.19 vs. 247.47 ± 38.63 μg/l). In DS, HEX induced a clear GH response (HEX vs. placebo, AUC 1,900.5 ± 301.7 vs. 116.1 ± 24.8 μg/l/h; p <0.0001) which was higher (p <0.05) than that after GHRH (1,051.0 ± 231.9 μg/l/h). The CH responses to HEX and to GHRH were similar in DS and in NC (AUC 1,936.0 ± 306.5 and 873.8 ± 190.3 μg/l/h). The effect of HEX was higher in pubertal than in prepubertal children (p <0.005). Thus, HEX releases more GH than GHRH also in DS, and the GH response to HEX as well as to GHRH is similar in DS and NC.
AB - We studied the effect of the maximum response dose of hexarelin (HEX), a potent GH-releasing peptide (His-D,2,methyl,Trp-Ala-Trp-D,Phe-Lys-NH2) (HEX, 2 μg/kg i.v. at 0 min), comparing it with that of GHRH (2 μg/kg i.v. at 0 min) in 15 children with Down syndrome (DS, 10 M and 5 F, 7.5-15 years) and in 15 normal short children (NC, 9 M and 6 F, 8.2-15.5 years). Basal IGF-I levels were similar in DS and NC (313.85 ± 41.19 vs. 247.47 ± 38.63 μg/l). In DS, HEX induced a clear GH response (HEX vs. placebo, AUC 1,900.5 ± 301.7 vs. 116.1 ± 24.8 μg/l/h; p <0.0001) which was higher (p <0.05) than that after GHRH (1,051.0 ± 231.9 μg/l/h). The CH responses to HEX and to GHRH were similar in DS and in NC (AUC 1,936.0 ± 306.5 and 873.8 ± 190.3 μg/l/h). The effect of HEX was higher in pubertal than in prepubertal children (p <0.005). Thus, HEX releases more GH than GHRH also in DS, and the GH response to HEX as well as to GHRH is similar in DS and NC.
KW - Down syndrome
KW - Growth hormone
KW - Growth hormone-releasing hormone
KW - Hexarelin
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M3 - Article
AN - SCOPUS:9444298410
VL - 9
SP - 204
EP - 210
JO - Developmental Brain Dysfunction
JF - Developmental Brain Dysfunction
SN - 1019-5815
IS - 4
ER -