Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia

Marta Maschio, Francesco Marchesi, Sabrina Dispenza, Loredana Dinapoli, Francesca Sperati, Gianluca Petreri, Svitlana Gumenyuk, Maria Laura Dessanti, Alessia Zarabla, Tonino Cantelmi, Andrea Mengarelli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background EEG activity is considered an index of functional state of brain. Chemotherapy (CT), used for non-central nervous system (CNS) cancer, can cross the blood brain barrier and contribute to changes in the functional state of brain that can alter background EEG activity. Quantitative EEG (qEEG) is superior to conventional EEG in the detection of subtle alterations of EEG background activity and for this reason, the use of qEEG might assist the clinician in evaluating the possible effect of CT on the CNS. The nucleoside analog cytosine arabinoside (Ara-C) is one of the milestone chemotherapeutic agents used for treatment of acute myeloid leukemia (AML). Our observational study evaluates the possible effect of Ara-C on the qEEG of patients with AML, without CNS involvement. We conducted an observational study on newly diagnosed AML patients without CNS involvement, undergoing treatment with Ara-C to analyze the possible effect of Ara-C high doses on EEG background activity using qEEG analyses. A total of nine AML patients, 5 with Ara-C i.v. high dose (≥3 g/m2 die), 4 with standard dose (100 mg/m2 die) underwent qEEG (at rest, during hyperpnoea, mental arithmetic task and blocking reaction). We compared the EEG background activity of the two groups at baseline and after 6 months. Statistical analysis showed no significant differences between the two groups in mean relative power for all frequency bands, at rest and during hyperpnoea, mental arithmetic task and blocking reaction. Our data indicate that high dose Ara-C i.v. did not induce significant changes on EEG background activity in our patients. Future research in this area could include prospective studies that would combine qEEG and neuropsychological testing to assess the impact of CT on brain functions.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCognitive Neurodynamics
DOIs
Publication statusAccepted/In press - Jan 13 2016

Fingerprint

Cytarabine
Acute Myeloid Leukemia
Electroencephalography
Central Nervous System
Drug Therapy
Observational Studies
Brain
Blood-Brain Barrier
Nucleosides
Nervous System

Keywords

  • Acute myeloid leukemia
  • CNS
  • High dose cytosine arabinoside
  • qEEG

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia. / Maschio, Marta; Marchesi, Francesco; Dispenza, Sabrina; Dinapoli, Loredana; Sperati, Francesca; Petreri, Gianluca; Gumenyuk, Svitlana; Dessanti, Maria Laura; Zarabla, Alessia; Cantelmi, Tonino; Mengarelli, Andrea.

In: Cognitive Neurodynamics, 13.01.2016, p. 1-4.

Research output: Contribution to journalArticle

Maschio, M, Marchesi, F, Dispenza, S, Dinapoli, L, Sperati, F, Petreri, G, Gumenyuk, S, Dessanti, ML, Zarabla, A, Cantelmi, T & Mengarelli, A 2016, 'Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia', Cognitive Neurodynamics, pp. 1-4. https://doi.org/10.1007/s11571-015-9370-0
Maschio, Marta ; Marchesi, Francesco ; Dispenza, Sabrina ; Dinapoli, Loredana ; Sperati, Francesca ; Petreri, Gianluca ; Gumenyuk, Svitlana ; Dessanti, Maria Laura ; Zarabla, Alessia ; Cantelmi, Tonino ; Mengarelli, Andrea. / Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia. In: Cognitive Neurodynamics. 2016 ; pp. 1-4.
@article{ae4805a5a3c842e8996d36cd169dc9ec,
title = "Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia",
abstract = "Background EEG activity is considered an index of functional state of brain. Chemotherapy (CT), used for non-central nervous system (CNS) cancer, can cross the blood brain barrier and contribute to changes in the functional state of brain that can alter background EEG activity. Quantitative EEG (qEEG) is superior to conventional EEG in the detection of subtle alterations of EEG background activity and for this reason, the use of qEEG might assist the clinician in evaluating the possible effect of CT on the CNS. The nucleoside analog cytosine arabinoside (Ara-C) is one of the milestone chemotherapeutic agents used for treatment of acute myeloid leukemia (AML). Our observational study evaluates the possible effect of Ara-C on the qEEG of patients with AML, without CNS involvement. We conducted an observational study on newly diagnosed AML patients without CNS involvement, undergoing treatment with Ara-C to analyze the possible effect of Ara-C high doses on EEG background activity using qEEG analyses. A total of nine AML patients, 5 with Ara-C i.v. high dose (≥3 g/m2 die), 4 with standard dose (100 mg/m2 die) underwent qEEG (at rest, during hyperpnoea, mental arithmetic task and blocking reaction). We compared the EEG background activity of the two groups at baseline and after 6 months. Statistical analysis showed no significant differences between the two groups in mean relative power for all frequency bands, at rest and during hyperpnoea, mental arithmetic task and blocking reaction. Our data indicate that high dose Ara-C i.v. did not induce significant changes on EEG background activity in our patients. Future research in this area could include prospective studies that would combine qEEG and neuropsychological testing to assess the impact of CT on brain functions.",
keywords = "Acute myeloid leukemia, CNS, High dose cytosine arabinoside, qEEG",
author = "Marta Maschio and Francesco Marchesi and Sabrina Dispenza and Loredana Dinapoli and Francesca Sperati and Gianluca Petreri and Svitlana Gumenyuk and Dessanti, {Maria Laura} and Alessia Zarabla and Tonino Cantelmi and Andrea Mengarelli",
year = "2016",
month = "1",
day = "13",
doi = "10.1007/s11571-015-9370-0",
language = "English",
pages = "1--4",
journal = "Cognitive Neurodynamics",
issn = "1871-4080",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia

AU - Maschio, Marta

AU - Marchesi, Francesco

AU - Dispenza, Sabrina

AU - Dinapoli, Loredana

AU - Sperati, Francesca

AU - Petreri, Gianluca

AU - Gumenyuk, Svitlana

AU - Dessanti, Maria Laura

AU - Zarabla, Alessia

AU - Cantelmi, Tonino

AU - Mengarelli, Andrea

PY - 2016/1/13

Y1 - 2016/1/13

N2 - Background EEG activity is considered an index of functional state of brain. Chemotherapy (CT), used for non-central nervous system (CNS) cancer, can cross the blood brain barrier and contribute to changes in the functional state of brain that can alter background EEG activity. Quantitative EEG (qEEG) is superior to conventional EEG in the detection of subtle alterations of EEG background activity and for this reason, the use of qEEG might assist the clinician in evaluating the possible effect of CT on the CNS. The nucleoside analog cytosine arabinoside (Ara-C) is one of the milestone chemotherapeutic agents used for treatment of acute myeloid leukemia (AML). Our observational study evaluates the possible effect of Ara-C on the qEEG of patients with AML, without CNS involvement. We conducted an observational study on newly diagnosed AML patients without CNS involvement, undergoing treatment with Ara-C to analyze the possible effect of Ara-C high doses on EEG background activity using qEEG analyses. A total of nine AML patients, 5 with Ara-C i.v. high dose (≥3 g/m2 die), 4 with standard dose (100 mg/m2 die) underwent qEEG (at rest, during hyperpnoea, mental arithmetic task and blocking reaction). We compared the EEG background activity of the two groups at baseline and after 6 months. Statistical analysis showed no significant differences between the two groups in mean relative power for all frequency bands, at rest and during hyperpnoea, mental arithmetic task and blocking reaction. Our data indicate that high dose Ara-C i.v. did not induce significant changes on EEG background activity in our patients. Future research in this area could include prospective studies that would combine qEEG and neuropsychological testing to assess the impact of CT on brain functions.

AB - Background EEG activity is considered an index of functional state of brain. Chemotherapy (CT), used for non-central nervous system (CNS) cancer, can cross the blood brain barrier and contribute to changes in the functional state of brain that can alter background EEG activity. Quantitative EEG (qEEG) is superior to conventional EEG in the detection of subtle alterations of EEG background activity and for this reason, the use of qEEG might assist the clinician in evaluating the possible effect of CT on the CNS. The nucleoside analog cytosine arabinoside (Ara-C) is one of the milestone chemotherapeutic agents used for treatment of acute myeloid leukemia (AML). Our observational study evaluates the possible effect of Ara-C on the qEEG of patients with AML, without CNS involvement. We conducted an observational study on newly diagnosed AML patients without CNS involvement, undergoing treatment with Ara-C to analyze the possible effect of Ara-C high doses on EEG background activity using qEEG analyses. A total of nine AML patients, 5 with Ara-C i.v. high dose (≥3 g/m2 die), 4 with standard dose (100 mg/m2 die) underwent qEEG (at rest, during hyperpnoea, mental arithmetic task and blocking reaction). We compared the EEG background activity of the two groups at baseline and after 6 months. Statistical analysis showed no significant differences between the two groups in mean relative power for all frequency bands, at rest and during hyperpnoea, mental arithmetic task and blocking reaction. Our data indicate that high dose Ara-C i.v. did not induce significant changes on EEG background activity in our patients. Future research in this area could include prospective studies that would combine qEEG and neuropsychological testing to assess the impact of CT on brain functions.

KW - Acute myeloid leukemia

KW - CNS

KW - High dose cytosine arabinoside

KW - qEEG

UR - http://www.scopus.com/inward/record.url?scp=84954322974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954322974&partnerID=8YFLogxK

U2 - 10.1007/s11571-015-9370-0

DO - 10.1007/s11571-015-9370-0

M3 - Article

SP - 1

EP - 4

JO - Cognitive Neurodynamics

JF - Cognitive Neurodynamics

SN - 1871-4080

ER -