Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens

Giulia Landini, Tiziana Di Maggio, Francesco Sergio, Jean Denis Docquier, Gian Maria Rossolini, Lucia Pallecchi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.

Original languageEnglish
Pages (from-to)7513-7517
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens'. Together they form a unique fingerprint.

Cite this