TY - JOUR
T1 - Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens
AU - Landini, Giulia
AU - Di Maggio, Tiziana
AU - Sergio, Francesco
AU - Docquier, Jean Denis
AU - Rossolini, Gian Maria
AU - Pallecchi, Lucia
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.
AB - The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.
UR - http://www.scopus.com/inward/record.url?scp=84996564700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84996564700&partnerID=8YFLogxK
U2 - 10.1128/AAC.01334-16
DO - 10.1128/AAC.01334-16
M3 - Article
AN - SCOPUS:84996564700
VL - 60
SP - 7513
EP - 7517
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 12
ER -