Effect of highly active antiretroviral therapy on the incidence of bacterial pneumonia in HIV-infected subjects

K. De Gaetano Donati, S. Bertagnolio, M. Tumbarello, E. Tacconelli, M. Cataldo, B. Longo, R. Cauda

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to assess the incidence of hospital and community acquired bacterial pneumonia in HIV-infected subjects prior to and after the introduction of highly active antiretroviral therapy (HAART). We studied 266 patients with bacterial pneumonia over two separate periods, 154 in the first period and 112 in the second period. A statistically significant difference in the incidence of bacterial pneumonia in the two study periods was observed ranging from 13.1 to 8.5 episodes per 100 persons. The incidence of community-acquired bacterial pneumonia decreased from 10.7 to 7.7 (P = 0.01), while that of nosocomial episodes decreased from 2.4 to 0.8 episodes (P = 0.003). Low levels of peripheral CD4+ cells (<100/mm3) and intravenous drug abuse (IVDA) were significantly associated with the development of community-acquired bacterial pneumonia, while an increasing value of APACHE III score and prolonged hospitalisation increased the risk of nosocomial bacterial pneumonia in both study periods. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume16
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Bacterial pneumonia
  • HAART
  • HIV infection

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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