Histamine and 5 methylhistamine were studied in healthy volunteers for their stimulant effects on gastric acid secretion and cyclic AMP output. The effect of the methyl derivative was much more prolonged than that of histamine and this was particularly evident after discontinuing the infusion of the two secretagogues. From this moment to the end of the experiments both HCl and cAMP outputs were significantly higher after 5 methylhistamine than after histamine administration. It is suggested that the increase in cAMP levels as well as in HCl secretion is connected with stimulation of gastric H2 receptors by histamine and, even more specifically, by the methyl derivative. In this investigation the lack of harmful side effects following 5 methylhistamine administration, already observed in previous studies, was confirmed.
|Number of pages||4|
|Journal||Rendiconti di Gastro-Enterologia|
|Publication status||Published - 1976|
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