Effect of hormone therapy on exercise capacity in early postmenopausal women

Giuseppe Mercuro, Francesca Saiu, Martino Deidda, Silvia Mercuro, Cristiana Vitale, G. M C Rosano

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To compare the exercise capacity of postmenopausal women with matched premenopausal controls, as well as postmenopausal women before and after 3 months of hormone therapy (HT). METHODS: This study examined the response to strenuous isotonic exercise in 30 women with recently developed menopause (age, mean±standard deviation, 50.6±1.1 years) without cardiovascular risk factors or diseases. Thirty premenopausal subjects, matched one-to-one for age and biophysical characteristics, were the control group. Postmenopausal women underwent examination before (T0) and 3 months after (T1) HT (oral 0.625 mg conjugated estrogen and 2.5 mg medroxyprogesterone acetate/day) with high-resolution ultrasound determination of peripheral flow-mediated vasodilation and an integrative cardiopulmonary test. RESULTS: Postmenopausal women showed an impairment of flow-mediated vasodilation (P

Original languageEnglish
Pages (from-to)780-787
Number of pages8
JournalObstetrics and Gynecology
Volume110
Issue number4
DOIs
Publication statusPublished - Oct 2007

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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