Effect of hypergravity on the mouse basal expression of NGF and BDNF in the retina, visual cortex and geniculate nucleus: Correlative aspects with NPY immunoreactivity

L. Aloe, M. Fiore, D. Santucci, T. Amendola, A. Antonelli, N. Francia, G. Corazzi, E. Alleva

Research output: Contribution to journalArticle

Abstract

We investigated the effect of hypergravitation on Nerve growth factor (NGF) and Brain-derived-neurotrophic factor (BDNF) expression in the visual cortex, geniculate nucleus (GN), and retina of adult male mice. The results showed that altered gravity causes an increase in NGF and BDNF in the visual cortex and GN which resulted to be associated with an up-regulation of cells immunoreactive to neuropeptide Y (NPY) in the visual cortex and GN. We also found a decrease in NGF, BDNF, and NPY in the mouse retina exposed to hypergravity. These findings suggest that alteration in gravitational environment differentially affects local neurotrophic factors and NPY expression. The possible functional significance of these observations is discussed.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume302
Issue number1
DOIs
Publication statusPublished - Apr 13 2001

Keywords

  • Hypergravity
  • Neuropeptide Y
  • Neurotrophins
  • Visual system

ASJC Scopus subject areas

  • Neuroscience(all)

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