Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk

Giuseppe Mercuro, Cristiana Vitale, Elena Cerquetani, Sandra Zoncu, Martino Deidda, Massimo Fini, Giuseppe M C Rosano

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to evaluate the effect of increased serum uric acid (UA) levels and their therapeutic reduction with allopurinol on endothelium-dependent dilation in subjects with a high cardiovascular (CV) risk but who were free from clinical CV disease. Patients with hyperuricemia had impaired flow-mediated dilation (FMD) compared with matched controls with normal UA levels and elevated CV risk. Three-month therapy with allopurinol improved FMD in hyperuricemic subjects, showing an intrinsic negative effect of elevated UA levels on the arterial wall; conversely, FMD remained unchanged in controls, thus suggesting that the reduction of UA to less than a certain value does not affect endothelial function.

Original languageEnglish
Pages (from-to)932-935
Number of pages4
JournalThe American Journal of Cardiology
Volume94
Issue number7
DOIs
Publication statusPublished - Oct 1 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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