Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk

Giuseppe Mercuro, Cristiana Vitale, Elena Cerquetani, Sandra Zoncu, Martino Deidda, Massimo Fini, Giuseppe M C Rosano

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

The aim of the present study was to evaluate the effect of increased serum uric acid (UA) levels and their therapeutic reduction with allopurinol on endothelium-dependent dilation in subjects with a high cardiovascular (CV) risk but who were free from clinical CV disease. Patients with hyperuricemia had impaired flow-mediated dilation (FMD) compared with matched controls with normal UA levels and elevated CV risk. Three-month therapy with allopurinol improved FMD in hyperuricemic subjects, showing an intrinsic negative effect of elevated UA levels on the arterial wall; conversely, FMD remained unchanged in controls, thus suggesting that the reduction of UA to less than a certain value does not affect endothelial function.

Original languageEnglish
Pages (from-to)932-935
Number of pages4
JournalThe American Journal of Cardiology
Volume94
Issue number7
DOIs
Publication statusPublished - Oct 1 2004

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Hyperuricemia
Uric Acid
Dilatation
Allopurinol
Endothelium
Cardiovascular Diseases
Therapeutics
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk. / Mercuro, Giuseppe; Vitale, Cristiana; Cerquetani, Elena; Zoncu, Sandra; Deidda, Martino; Fini, Massimo; Rosano, Giuseppe M C.

In: The American Journal of Cardiology, Vol. 94, No. 7, 01.10.2004, p. 932-935.

Research output: Contribution to journalArticle

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