Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients

Fulvio Baggi, Federica Ubiali, Sara Nava, Valeria Nessi, Francesca Andreetta, Andrea Rigamonti, Lorenzo Maggi, Renato Mantegazza, Carlo Antozzi

Research output: Contribution to journalArticle

Abstract

We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalJournal of Neuroimmunology
Volume201-202
Issue numberC
DOIs
Publication statusPublished - Sep 15 2008

Keywords

  • Immunoadsorption
  • Lambert-Eaton Myasthenic Syndrome
  • Myasthenia Gravis
  • Neuroimmunology

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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