Effect of ileal infusion of glycochenodeoxycholic acid on segmental transit, motility, and flow in the human jejunum and ileum

R. Penagini, R. C. Spiller, J. J. Misiewicz, P. G. Frost

Research output: Contribution to journalArticle


The hypothesis that the presence of glycochenodeoxycholic acid (GCDC) in the human Heal bile acid concentrations showed a 54·0 (9·3)% absorption of glycochenodeoxycholic acid by the been tested in healthy volunteers. Mean transit times, flow rates and intraluminal pressures in a 40 cm jejunal segment proximal (n=6) and a 40 cm ileal segment distal (n=6) to a GCDC infusion port were measured. During GCDC infusion (60 μmol/min) jejunal and ileal transit were markedly (p

Original languageEnglish
Pages (from-to)609-617
Number of pages9
Issue number5
Publication statusPublished - May 1989


ASJC Scopus subject areas

  • Gastroenterology

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