Abstract
Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 281-283 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1972 |
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Keywords
- 5-Hydroxyindolacetic acid
- Desipramine
- Imipramine
- Midbrain raphe electrical stimulation
- Serotonin
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats. / Samanin, R.; Ghezzi, D.; Garattini, S.
In: European Journal of Pharmacology, Vol. 20, No. 3, 1972, p. 281-283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats
AU - Samanin, R.
AU - Ghezzi, D.
AU - Garattini, S.
PY - 1972
Y1 - 1972
N2 - Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.
AB - Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.
KW - 5-Hydroxyindolacetic acid
KW - Desipramine
KW - Imipramine
KW - Midbrain raphe electrical stimulation
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0015462982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015462982&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(72)90186-0
DO - 10.1016/0014-2999(72)90186-0
M3 - Article
C2 - 4643449
AN - SCOPUS:0015462982
VL - 20
SP - 281
EP - 283
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -