Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats

R. Samanin; D. Ghezzi; S. Garattini

doi:10.1016/0014-2999(72)90186-0

Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats

R. Samanin, D. Ghezzi, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.

Original language	English
Pages (from-to)	281-283
Number of pages	3
Journal	European Journal of Pharmacology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(72)90186-0
Publication status	Published - 1972

Keywords

5-Hydroxyindolacetic acid
Desipramine
Imipramine
Midbrain raphe electrical stimulation
Serotonin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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title = "Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats",

abstract = "Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.",

keywords = "5-Hydroxyindolacetic acid, Desipramine, Imipramine, Midbrain raphe electrical stimulation, Serotonin",

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AU - Ghezzi, D.

AU - Garattini, S.

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KW - Midbrain raphe electrical stimulation

KW - Serotonin

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