Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.
- 5-Hydroxyindolacetic acid
- Midbrain raphe electrical stimulation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience