Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats

R. Samanin, D. Ghezzi, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalEuropean Journal of Pharmacology
Volume20
Issue number3
DOIs
Publication statusPublished - 1972

Keywords

  • 5-Hydroxyindolacetic acid
  • Desipramine
  • Imipramine
  • Midbrain raphe electrical stimulation
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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