Abstract
Imipramine, 5 mg/kg, i.p., completely blocked the forebrain 5-HIAA increase in rats that have undergone midbrain raphe stimulation whereas desipramine, 5 mg/kg, i.p., did not. This finding is compatible with the hypothesis that imipramine can block selectively the membrane uptake of serotonin in the central serotoninergic neurons.
Original language | English |
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Pages (from-to) | 281-283 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 20 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1972 |
Keywords
- 5-Hydroxyindolacetic acid
- Desipramine
- Imipramine
- Midbrain raphe electrical stimulation
- Serotonin
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology