Effect of increasing the fat content but not the energy load of a meal on gastro-oesophageal reflux and lower oesophageal sphincter motor function

R. Penagini, M. Mangano, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Background - Although fatty foods are commonly considered detrimental in patients with reflux disease, no objective data exist that substantiate this belief. Aims - To investigate the effect of fat on gastro-oesophageal reflux and lower oesophageal sphincter (LOS) motor activity. Subjects-Thirteen healthy subjects and 14 patients with reflux disease. Methods - Oesophageal pH, LOS, and oesophageal pressures were recorded for 180 minutes after a high fat (52% fat) and a balanced (24% fat) meal (both 3.18 MJ) on two different occasions. Eight controls and seven patients were studied in the recumbent position and the others in the sitting position. Results - The percentage of time at pH less than 4 and the rate of reflux episodes were higher (p

Original languageEnglish
Pages (from-to)330-333
Number of pages4
JournalGut
Volume42
Issue number3
Publication statusPublished - 1998

Keywords

  • Fat
  • Gastro-oesophageal reflux
  • Oesophagogastric junction
  • Oesophagus

ASJC Scopus subject areas

  • Gastroenterology

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