Effect of individualizing starting doses of a statin according to baseline LDL-cholesterol levels on achieving cholesterol targets: The Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (ACTFAST) study

P. Martineau, A. Gaw, E. de Teresa, C. Farsang, G. F. Gensini, L. A. Leiter, A. Langer

Research output: Contribution to journalArticle

Abstract

Aims: To investigate whether selecting the starting dose of atorvastatin according to baseline and target (2.6 mmol/L (100 mg/dL) but ≤5.7 mmol/L (220 mg/dL) were assigned a starting dose of atorvastatin (10, 20, 40 or 80 mg/day) based on LDL-C and status of statin use at baseline, with a single uptitration at 6 weeks, if required. There was no washout for ST subjects. At study end, 80% of SF (82%, 82%, 83% and 72% with 10, 20, 40 and 80 mg, respectively) and 59% of ST (60%, 61% and 51% with 20, 40 and 80 mg, respectively) subjects reached LDL-C target. In the ST group, an additional 21-41% reduction in LDL-C was observed over the statin used at baseline. Atorvastatin was well tolerated. Conclusion: This study confirms that individualizing the starting dose of atorvastatin according to baseline and target LDL-C values (i.e. the required LDL-C reduction), allows a large majority of high-risk subjects to achieve target safely, within 12 weeks, with the initial dose or with a single titration.

Original languageEnglish
Pages (from-to)135-146
Number of pages12
JournalAtherosclerosis
Volume191
Issue number1
DOIs
Publication statusPublished - Mar 2007

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Keywords

  • Atorvastatin
  • Coronary heart disease
  • Diabetes
  • HMG CoA reductase inhibitors
  • Low density lipoprotein-cholesterol
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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