L'effetto dell'insulina sull'attività di fosfatasi alcalina dell'osso in coltura.

Translated title of the contribution: Effect of insulin on the activity of bone alkaline phosphatase in culture

A. Rubinacci, F. Boniforti, L. Tessari

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes and osteoporosis are linked. The question remains, however, as to whether insulin has any direct effect on bone formation. To test this hypothesis we have measured, as a marker of osteoblast activity, alkaline phosphatase (ALP) released by rat limb intact bones incubated in the presence and in the absence of physiological concentration of insulin. The results indicate that insulin significantly (p less than 0.012) increases ALP by a mean value of 48% (from 5.4% to 215%) over matched controls. We conclude that insulin has a direct stimulatory effect on osteoblast activity, and that in the absence of this effect, as in diabetes, bone loss might occur.

Translated title of the contributionEffect of insulin on the activity of bone alkaline phosphatase in culture
Original languageItalian
Pages (from-to)187-191
Number of pages5
JournalMinerva Endocrinologica
Volume16
Issue number4
Publication statusPublished - Oct 1991

ASJC Scopus subject areas

  • Medicine(all)

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