Effect of insulin receptor autophosphorylation on insulin receptor binding

Roberto Gherzi, Gabriella Andraghetti, Giorgio Versari, Renzo Cordera

Research output: Contribution to journalArticlepeer-review

Abstract

Insulin receptor beta-subunit autophosphorylation, the first event occurring after insulin binding, plays a crucial role in modulation of receptor-associated kinase activity towards exogenous substrates and possibly in the transmission of biological signals of insulin. Receptor autophosphorylation strongly depends on insulin receptor occupancy. Till now the effects of receptor phosphorylation on insulin binding itself have not been clarified. In the present report we demonstrate the absence of any feedback mechanism by which insulin receptor activation by phosphorylation affects binding affinity of insulin receptor itself.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume45
Issue number2-3
DOIs
Publication statusPublished - 1986

Keywords

  • insulin receptor
  • PEG precipitation
  • receptor phosphorylation
  • receptor purification

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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