Effect of interferon-α therapy in a patient with common variable immunodeficiency and chronic epstein-Barr virus infection

Roberto Toraldo; Michele D'Avanzo; Carlo Tolone; Gianfranco Canino; Ferdinando Lafusco; Luigi Daniele Notarangelo; Alberto Ugazio; Carmela Cirillo

doi:10.3109/08880019509009480

Effect of interferon-α therapy in a patient with common variable immunodeficiency and chronic epstein-Barr virus infection

Roberto Toraldo, Michele D'Avanzo, Carlo Tolone, Gianfranco Canino, Ferdinando Lafusco, Luigi Daniele Notarangelo, Alberto Ugazio, Carmela Cirillo

Research output: Contribution to journal › Article › peer-review

Abstract

We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was delected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-α (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-α is a valid alternative in therapy of immunodeficient EB virus-infected patients.

Original language	English
Pages (from-to)	489-493
Number of pages	5
Journal	Pediatric Hematology and Oncology
Volume	12
Issue number	5
DOIs	https://doi.org/10.3109/08880019509009480
Publication status	Published - 1995

Keywords

Common variable immunodeficiency
Epstein-Barr virus
Interferon-α

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology
Cancer Research
Management of Technology and Innovation

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10.3109/08880019509009480

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title = "Effect of interferon-α therapy in a patient with common variable immunodeficiency and chronic epstein-Barr virus infection",

abstract = "We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was delected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-α (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-α is a valid alternative in therapy of immunodeficient EB virus-infected patients.",

keywords = "Common variable immunodeficiency, Epstein-Barr virus, Interferon-α",

author = "Roberto Toraldo and Michele D'Avanzo and Carlo Tolone and Gianfranco Canino and Ferdinando Lafusco and Notarangelo, {Luigi Daniele} and Alberto Ugazio and Carmela Cirillo",

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doi = "10.3109/08880019509009480",

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AU - Toraldo, Roberto

AU - D'Avanzo, Michele

AU - Tolone, Carlo

AU - Canino, Gianfranco

AU - Lafusco, Ferdinando

AU - Notarangelo, Luigi Daniele

AU - Ugazio, Alberto

AU - Cirillo, Carmela

PY - 1995

Y1 - 1995

N2 - We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was delected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-α (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-α is a valid alternative in therapy of immunodeficient EB virus-infected patients.

AB - We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was delected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-α (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-α is a valid alternative in therapy of immunodeficient EB virus-infected patients.

KW - Common variable immunodeficiency

KW - Epstein-Barr virus

KW - Interferon-α

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ER -

Effect of interferon-α therapy in a patient with common variable immunodeficiency and chronic epstein-Barr virus infection

Abstract

Keywords

ASJC Scopus subject areas

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