Effect of interferon-α therapy in a patient with common variable immunodeficiency and chronic epstein-Barr virus infection

Roberto Toraldo, Michele D'Avanzo, Carlo Tolone, Gianfranco Canino, Ferdinando Lafusco, Luigi Daniele Notarangelo, Alberto Ugazio, Carmela Cirillo

Research output: Contribution to journalArticlepeer-review

Abstract

We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was delected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-α (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-α is a valid alternative in therapy of immunodeficient EB virus-infected patients.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalPediatric Hematology and Oncology
Volume12
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • Common variable immunodeficiency
  • Epstein-Barr virus
  • Interferon-α

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

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