Effect of interleukin-1-beta on metastasis formation in different tumor systems

M. R. Bani, A. Garofalo, E. Scanziani, R. Giavazzi

Research output: Contribution to journalArticlepeer-review


Experiments were done to determine the effect of interleukin-1-beta (IL-1β) on metastasis formation in different tumor systems. Intravenous administration of 1 μg of human recombinant IL-1β given 1 hour before tumor cell injection augmented lung colony formation (experimental metastases) by the human A375 melanoma variants, the human HT-29M colon carcinoma, the SN12-K1 renal carcinoma in nude mice, the murine B16 melanoma variants, and the murine UV-2237M fibrosarcoma in syngeneic recipients. The same treatment did not induce lung colony formation by a human rectal carcinoma (HCC-P2988) or by a murine reticulum cell sarcoma (M5076), both of which are not metastatic to the lung. Spontaneous metastases were studied in C57BL/6 mice bearing the B16-BL6 melanoma (metastatic to the lung) in their footpad and the M5076 reticulum cell sarcoma (metastatic to the liver) subcutaneously. Daily intraperitoneal treatment with 1 μg of IL-1β increased lung and liver metastases. These findings indicate that treatment of mice with IL-1β can increase the number of artificial or spontaneous metastases and that this effect is not limited to a single tumor type or to a specific organ.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalJournal of the National Cancer Institute
Issue number2
Publication statusPublished - Jan 16 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging


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