Effect of interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe

Daniel Kelberman, E. Hawe, L. Ahn Luong, Vidya Mohamed-Ali, Pia Lundman, Per Tornvall, M. F. Aillaud, Irène Juhan-Vague, John S. Yudkin, Maurizio Margaglione, Giovanni di Minno, Elena Tremoli, Stephen E. Humphries, A. Hamsten, S. Boquist, C. G. Ericsson, A. Samnegard, A. Silveira, A. Holmes, P. E. MorangeM. C. Alessi, P. Ambrosi, I. Canavy, F. Paganelli, R. Didelot, J. Ansaldi, M. Billery, D. Colaizzo, N. Dello Iacono, A. Cimino, G. Gaeta, C. Blasich, G. Pucciarelli, V. van Hinsbergh, T. Kooistra, C. Banfi, L. Mussoni

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p <0.0005), where -174C allele carriers showed an apparent reduced risk of MI compared to -174GG homozygotes (OR 0.53, 95%CI 0.32, 0.86). No such effect was observed in the South or with the -572G>C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe.

Original languageEnglish
Pages (from-to)1122-1128
Number of pages7
JournalThrombosis and Haemostasis
Volume92
Issue number5
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Coronary heart disease
  • Interleukin 6
  • Myocardial infarction

ASJC Scopus subject areas

  • Hematology

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