Effect of intralipid® on some immunological parameters and leukocyte functions in patients with esophageal and gastric cancer

P. Dionigi, R. Dionigi, U. Prati, F. Pavesi, V. Jemos, S. Nazari

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study has been undertaken to investigate if the intravenous (i.v.) infusion of fat emulsions may be associated with impairment of some immunological functions thus increasing the risk of septic complications. Fifteen malnourished patients with advanced gastric or esophageal cancer received for 2 weeks preoperatively and 1 week after surgery an isocaloric and isonitrogenous TPN treatment with Intralipid® (group A: n=8) or glucose alone (group B: n=7) as energy substrate. Cluster analysis of 11 nutritional parameters and some tests of the humoral and cellular immunity (IgG, IgM, C3c, Factor B; polymorphonuclear (PMN) cells, total lymphocytes, T and B lymphocyte counts; 'in vitro' PMN chemotaxis, adherence to nylon fibers, phagocytosis of latex particles) were sequentially determined. The incidence and severity of post-operative infections were investigated and a 'sepsis score' was calculated for each patient. Pre- and postoperative TPN were not associated with an improvement of the nutritional status. The humoral and cellular immune parameters showed the same behaviour in patients receiving Intralipid® and in controls. The chemotactic activity of PMN cells was constantly normal, granulocyte adherence fluctuated below the normality range in controls, whereas phagocytosis of latex was similar in both groups. Post-operative infectious episodes were less severe in patients receiving Intralipid.® Our results do not confirm that Intralipid® adversely affects some aspects of the humoral and cellular immune response.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalClinical Nutrition
Volume4
Issue number4
DOIs
Publication statusPublished - 1985

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Esophageal Neoplasms
Stomach Neoplasms
Leukocytes
Humoral Immunity
Phagocytosis
Cellular Immunity
Intravenous Fat Emulsions
Nylons
Latex
Lymphocyte Count
Chemotaxis
Nutritional Status
Microspheres
Granulocytes
Intravenous Infusions
Immunoglobulin M
Cluster Analysis
Sepsis
B-Lymphocytes
Immunoglobulin G

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)

Cite this

Effect of intralipid® on some immunological parameters and leukocyte functions in patients with esophageal and gastric cancer. / Dionigi, P.; Dionigi, R.; Prati, U.; Pavesi, F.; Jemos, V.; Nazari, S.

In: Clinical Nutrition, Vol. 4, No. 4, 1985, p. 229-234.

Research output: Contribution to journalArticle

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