Effect of intrauterine growth retardation on liver and long-term metabolic risk

S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli

Research output: Contribution to journalArticlepeer-review


Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction.International Journal of Obesity advance online publication, 24 April 2012; doi:10.1038/ijo.2012.54.

Original languageEnglish
JournalInternational Journal of Obesity
Publication statusAccepted/In press - Apr 24 2012

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Medicine (miscellaneous)

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