Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia

G. Barbano, M. N. Saleh, P. G. Mori, A. F. LoBuglio, D. R. Shaw

Research output: Contribution to journalArticle

Abstract

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects other than a substantive reduction in platelet reactive antibodies, such as the alteration of IgG-coated platelet destruction.

Original languageEnglish
Pages (from-to)662-665
Number of pages4
JournalBlood
Volume73
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology

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    Barbano, G., Saleh, M. N., Mori, P. G., LoBuglio, A. F., & Shaw, D. R. (1989). Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia. Blood, 73(3), 662-665.