Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging

Akos Varga-Szemes, Rob J. van der Geest, U. Joseph Schoepf, Bruce S. Spottiswoode, Carlo N. De Cecco, Giuseppe Muscogiuri, Julian L. Wichmann, Stefanie Mangold, Stephen R. Fuller, Pal Maurovich-Horvat, Bela Merkely, Sheldon E. Litwin, Rozemarijn Vliegenthart, Pal Suranyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms • Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.

Original languageEnglish
Pages (from-to)3235-3243
Number of pages9
JournalEuropean Radiology
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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Gadolinium
Myocardial Infarction
Image Enhancement
Analysis of Variance

Keywords

  • Cardiovascular magnetic resonance
  • Late gadolinium enhancement
  • Myocardial infarct
  • Synthetic inversion recovery
  • T1 mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging. / Varga-Szemes, Akos; van der Geest, Rob J.; Schoepf, U. Joseph; Spottiswoode, Bruce S.; De Cecco, Carlo N.; Muscogiuri, Giuseppe; Wichmann, Julian L.; Mangold, Stefanie; Fuller, Stephen R.; Maurovich-Horvat, Pal; Merkely, Bela; Litwin, Sheldon E.; Vliegenthart, Rozemarijn; Suranyi, Pal.

In: European Radiology, Vol. 27, No. 8, 01.08.2017, p. 3235-3243.

Research output: Contribution to journalArticle

Varga-Szemes, A, van der Geest, RJ, Schoepf, UJ, Spottiswoode, BS, De Cecco, CN, Muscogiuri, G, Wichmann, JL, Mangold, S, Fuller, SR, Maurovich-Horvat, P, Merkely, B, Litwin, SE, Vliegenthart, R & Suranyi, P 2017, 'Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging', European Radiology, vol. 27, no. 8, pp. 3235-3243. https://doi.org/10.1007/s00330-016-4665-z
Varga-Szemes, Akos ; van der Geest, Rob J. ; Schoepf, U. Joseph ; Spottiswoode, Bruce S. ; De Cecco, Carlo N. ; Muscogiuri, Giuseppe ; Wichmann, Julian L. ; Mangold, Stefanie ; Fuller, Stephen R. ; Maurovich-Horvat, Pal ; Merkely, Bela ; Litwin, Sheldon E. ; Vliegenthart, Rozemarijn ; Suranyi, Pal. / Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging. In: European Radiology. 2017 ; Vol. 27, No. 8. pp. 3235-3243.
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abstract = "Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms • Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.",
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T1 - Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging

AU - Varga-Szemes, Akos

AU - van der Geest, Rob J.

AU - Schoepf, U. Joseph

AU - Spottiswoode, Bruce S.

AU - De Cecco, Carlo N.

AU - Muscogiuri, Giuseppe

AU - Wichmann, Julian L.

AU - Mangold, Stefanie

AU - Fuller, Stephen R.

AU - Maurovich-Horvat, Pal

AU - Merkely, Bela

AU - Litwin, Sheldon E.

AU - Vliegenthart, Rozemarijn

AU - Suranyi, Pal

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms • Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.

AB - Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI). Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance. Results: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods. Conclusions: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0. Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIRsyaccurately quantifies infarcts from TI0to TI0 + 150 ms • Fifteen minutes post-contrast PSIRsyprovides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.

KW - Cardiovascular magnetic resonance

KW - Late gadolinium enhancement

KW - Myocardial infarct

KW - Synthetic inversion recovery

KW - T1 mapping

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