Effect of iodinated contrast medium on thyroid function: a study in children undergoing cardiac computed tomography

Elena Belloni, Stefania Tentoni, Mariangela Valentina Puci, Francesco Avogliero, Daniele della Latta, Simona Storti, Baldassare Alberti, Antonio Bottoni, Chandra Bortolotto, Ilaria Fiorina, Cristina Montomoli, Dante Chiappino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Few studies, and with conflicting results, have evaluated the potential effects of iodinated contrast media on children’s thyroid function. Objective: To investigate the effects of iodinated contrast medium on thyroid function in neonates, infants and young children with congenital heart disease undergoing cardiac computed tomography (CT). Materials and methods: We retrospectively evaluated 10 neonates (group 1) and 23 infants and young children (group 2) without thyroid or renal disease for serum levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine before contrast-enhanced cardiac CT, 48 h after CT and at discharge from the hospital. Cardiac CT was performed with intravenous administration of 1.14±0.17 mL/kg of body weight of iopromide (containing 370 mg of iodine/mL). Results: Group 1 had a reduction of thyroid-stimulating hormone from baseline to 48 h post injection (P=0.002). Group 2 had a reduction of thyroid-stimulating hormone median levels from baseline to 48 h post injection and an increase from 48 h to discharge (P=0.0005 and P=0.0001, respectively). Conclusion: Intravenous iodinated contrast medium in children with congenital heart disease caused transient thyroid-stimulating hormone decrease 48 h after CT, with thyroid-stimulating hormone returning to normal range at discharge.

Original languageEnglish
Pages (from-to)1417-1422
Number of pages6
JournalPediatric Radiology
Volume48
Issue number10
DOIs
Publication statusPublished - 2018

Keywords

  • Children
  • Computed tomography
  • Congenital heart disease
  • Iodinated contrast agent
  • Thyroid function
  • Thyrotropin
  • Thyroxin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

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