Effect of ketanserin in primary aldosteronism

F. Mantero, S. Rocco, G. Opocher, D. Armanini, M. Boscaro, D. D’Agostino

Research output: Contribution to journalArticlepeer-review

Abstract

Serotonin is known to have aldosterone-stimulating properties in humans, which are counteracted by the serotonin-antagonist metergoline. Suppression of aldosterone levels by cyproheptadinc in patients with idiopathic aldosteronism has also been shown. Since ketanserin, a more specific 5-HT2-serotoninergic (5-HT2) antagonist, has been shown to affect aldosterone secretion in essential hypertension, we have further investigated this mechanism by injecting ketanserin (10 nag i.v.) in 10 patients with primary aldosteronism (four adenoma, six idiopathic aldosteronism). A transient decrease (20% when compared with the basal levels) of plasma aldosterone was seen at 30 min. A concomitant decrease of plasma cortisol was also noticed, whereas plasma renin activity and potassium did not change. Blood pressure decreased in all cases. These observations suggest that ketanserin acts directly at the adrenal level by interfering with a possible modulatory activity of serotonin. However, an adrenocorticotropic hormone-mediated effect cannot he completely ruled out at the present time.

Original languageEnglish
Pages (from-to)S172-S175
JournalJournal of Cardiovascular Pharmacology
Volume7
Publication statusPublished - 1985

Keywords

  • Aldosterone
  • Hypertension
  • Ketanserin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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