Effect of L-Acetylcarnitine on body composition in HIV-related lipodystrophy

S. Benedini, G. Perseghin, I. Terruzzi, P. Scifo, P. L. Invernizzi, A. Del Maschio, A. Lazzarin, L. Luzi

Research output: Contribution to journalArticle

Abstract

This study examined the impact of L-acetylcarnitine treatment on metabolic parameters and body composition in patients with lipodystrophy syndrome secondary to antiretroviral treatment in human immunodeficiency virus (HIV) infection. A total of 9 HIV-1 infected patients with lipodystrophy syndrome (4F/5M, age 41±5 years, HIV duration 8±2 years, BMI 23.7±3.4kg/m2, on protease inhibitors and nucleoside analogue Reverse Transcriptase inhibitors) were evaluated before and after 8 months of therapy with L-acetylcarnitine (2g/die) and 9 matched healthy subjects served as control subjects. In all patients fasting plasma glucose, insulin concentrations (for evaluation of surrogate indexes of insulin sensitivity), lipid profile, lipid oxidation (by indirect calorimetry), body composition (by DEXA), and intramyocellular triglyceride (IMCL) content of the calf muscles (by 1H NMR spectroscopy) were assessed. After this therapy, in HIV-1 patients, the IMCL content of the soleus had significantly decreased (p=0.03). Plasma FFAs (0.79±0.31 to 0.64±0.25; p

Original languageEnglish
Pages (from-to)840-845
Number of pages6
JournalHormone and Metabolic Research
Volume41
Issue number11
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Energy metabolism
  • Human immunodeficiency virus
  • Insulin sensitivity
  • Nmr spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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