Effect of lacidipine on pituitary function in essential hypertension.

G. Carpené, G. Opocher, G. Zanferrari, P. Rizzini, F. Mantero

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Calcium plays an important role in endocrine reactions such as hormone biosynthesis, release, secretion, and action on target organs. The aim of this study was to evaluate the effects of a new long-lasting calcium-channel blocker, lacidipine, on basal and stimulated anterior pituitary hormone secretion. In a single-blind crossover study comparing lacidipine 4 mg p.o. once daily with placebo, variations in plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyroid-stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH) were evaluated in 10 hypertensive patients. Basal or stimulated anterior pituitary hormone secretion was similar after lacidipine and placebo. Lacidipine treatment significantly reduced blood pressure. It can thus be concluded that lacidipine is an effective calcium antagonist that has no effect on pituitary function.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume18 Suppl 11
Publication statusPublished - 1991

Fingerprint

Anterior Pituitary Hormones
Placebos
Calcium
Single-Blind Method
L-Type Calcium Channels
Calcium Channel Blockers
Follicle Stimulating Hormone
Thyrotropin
Luteinizing Hormone
Prolactin
Adrenocorticotropic Hormone
Cross-Over Studies
lacidipine
Essential Hypertension
Hormones
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Carpené, G., Opocher, G., Zanferrari, G., Rizzini, P., & Mantero, F. (1991). Effect of lacidipine on pituitary function in essential hypertension. Journal of Cardiovascular Pharmacology, 18 Suppl 11.

Effect of lacidipine on pituitary function in essential hypertension. / Carpené, G.; Opocher, G.; Zanferrari, G.; Rizzini, P.; Mantero, F.

In: Journal of Cardiovascular Pharmacology, Vol. 18 Suppl 11, 1991.

Research output: Contribution to journalArticle

Carpené, G, Opocher, G, Zanferrari, G, Rizzini, P & Mantero, F 1991, 'Effect of lacidipine on pituitary function in essential hypertension.', Journal of Cardiovascular Pharmacology, vol. 18 Suppl 11.
Carpené, G. ; Opocher, G. ; Zanferrari, G. ; Rizzini, P. ; Mantero, F. / Effect of lacidipine on pituitary function in essential hypertension. In: Journal of Cardiovascular Pharmacology. 1991 ; Vol. 18 Suppl 11.
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