Effect of lead exposure on dopaminergic receptors in rat striatum and nucleus accumbens

S. Govoni, L. Lucchi, C. Missale, M. Memo, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Haloperidol- and sulpiride-displaceable [3H]spiroperidol binding and the dopamine-inhibited adenylate cyclase were measured in rats chronically exposed to lead acetate. Haloperidol-displaceable [3H]spiroperidol binding was unmodified while sulpiride-displaceable binding was increased in striatum and decreased in nucleus accumbens. In addition, the decrease of sulpiride-displaceable binding in nucleus accumbens was paralleled by a reduced ability of bromocriptine to inhibit cAMP formation in presence of the D1 receptor antagonist SCH 23390. The results support the concept that in vivo lead treatment affects dopaminergic receptors and that the binding sites labelled by [3H]spiroperidol displaced by haloperidol may be different from those which recognize sulpiride.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalBrain Research
Volume381
Issue number1
DOIs
Publication statusPublished - Aug 27 1986

Keywords

  • dopamine receptor
  • lead
  • nucleus accumbens
  • striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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