Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis

Francesco Giuseppe Foschi, Franco Trevisani, Elisabetta Loggi, Monica Parazza, Cristina Melotti, Enrico Bedeschi, Lorenza Mingazzini, Federica Mirici Cappa, Matteo Cescon, Pietro Andreone, Gianluca Grazi, Giuseppe Francesco Stefanini, Mauro Bernardi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function. Orthotopic liver transplantation (OLT) cures cirrhosis and might restore TA. This study was aimed at determining if OLT restores TA and PA. Methods: We measured in 9 cirrhotic patients, before and after successful OLT, TA by a bioassay and PA by chemiluminescence in which neutrophils of the patient were tested with both autologous (PA1) and pooled sera from healthy subjects (PA2). Splenic function was assayed by the pitted red cell count. Results: Before OLT, TA was reduced in 7 patients, and PA1 in all the patients. Pitted cell count was elevated in all the patients. After OLT (median 39 months; range 21-49), TA improved in all cases [median: from 8% (5-16%) to 20% (9-22%), p <0.008], normalizing in 5 out of the 7 patients with low values. PA1 improved in all the patients [from 102 cpm (65-128 cpm) to 235 cpm (78-280 cpm), p <0.008], normalizing in 5. Pitted red count decreased in 7 patients and normalized in 3 [from 3.3% (2.1-6.0%) to 2.4% (1.4-2.8%), p <0.021]. Platelet count [from 55 × 10 3 (30-100) to 185 × 10 3 (93-286), p <0.008] and leucocyte count [from 3.60 × 10 3 (1.81-5.23) to 5.53 × 10 3 (3.31-6.71), p <0.008] also improved. Conclusions: OLT improves TA and PA of cirrhotic patients. This effect is associated with an improvement of both functional hyposplenism and haematological hypersplenism. The restoration of natural defences against infections may mitigate the adverse effect of immunosuppressive treatment.

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume137
Issue number3
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Tuftsin
Granulocytes
Liver Cirrhosis
Liver Transplantation
Neutrophils
Fibrosis
Cell Count
Hypersplenism
Immunosuppressive Agents
Luminescence
Platelet Count
Leukocyte Count
Biological Assay
Healthy Volunteers

Keywords

  • Cirrhosis
  • Liver transplantation
  • Phagocytic activity and neutrophil granulocytes
  • Tuftsin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis. / Foschi, Francesco Giuseppe; Trevisani, Franco; Loggi, Elisabetta; Parazza, Monica; Melotti, Cristina; Bedeschi, Enrico; Mingazzini, Lorenza; Cappa, Federica Mirici; Cescon, Matteo; Andreone, Pietro; Grazi, Gianluca; Stefanini, Giuseppe Francesco; Bernardi, Mauro.

In: International Archives of Allergy and Immunology, Vol. 137, No. 3, 07.2005, p. 258-262.

Research output: Contribution to journalArticle

Foschi, FG, Trevisani, F, Loggi, E, Parazza, M, Melotti, C, Bedeschi, E, Mingazzini, L, Cappa, FM, Cescon, M, Andreone, P, Grazi, G, Stefanini, GF & Bernardi, M 2005, 'Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis', International Archives of Allergy and Immunology, vol. 137, no. 3, pp. 258-262. https://doi.org/10.1159/000086339
Foschi, Francesco Giuseppe ; Trevisani, Franco ; Loggi, Elisabetta ; Parazza, Monica ; Melotti, Cristina ; Bedeschi, Enrico ; Mingazzini, Lorenza ; Cappa, Federica Mirici ; Cescon, Matteo ; Andreone, Pietro ; Grazi, Gianluca ; Stefanini, Giuseppe Francesco ; Bernardi, Mauro. / Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis. In: International Archives of Allergy and Immunology. 2005 ; Vol. 137, No. 3. pp. 258-262.
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abstract = "Background: Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function. Orthotopic liver transplantation (OLT) cures cirrhosis and might restore TA. This study was aimed at determining if OLT restores TA and PA. Methods: We measured in 9 cirrhotic patients, before and after successful OLT, TA by a bioassay and PA by chemiluminescence in which neutrophils of the patient were tested with both autologous (PA1) and pooled sera from healthy subjects (PA2). Splenic function was assayed by the pitted red cell count. Results: Before OLT, TA was reduced in 7 patients, and PA1 in all the patients. Pitted cell count was elevated in all the patients. After OLT (median 39 months; range 21-49), TA improved in all cases [median: from 8{\%} (5-16{\%}) to 20{\%} (9-22{\%}), p <0.008], normalizing in 5 out of the 7 patients with low values. PA1 improved in all the patients [from 102 cpm (65-128 cpm) to 235 cpm (78-280 cpm), p <0.008], normalizing in 5. Pitted red count decreased in 7 patients and normalized in 3 [from 3.3{\%} (2.1-6.0{\%}) to 2.4{\%} (1.4-2.8{\%}), p <0.021]. Platelet count [from 55 × 10 3 (30-100) to 185 × 10 3 (93-286), p <0.008] and leucocyte count [from 3.60 × 10 3 (1.81-5.23) to 5.53 × 10 3 (3.31-6.71), p <0.008] also improved. Conclusions: OLT improves TA and PA of cirrhotic patients. This effect is associated with an improvement of both functional hyposplenism and haematological hypersplenism. The restoration of natural defences against infections may mitigate the adverse effect of immunosuppressive treatment.",
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T1 - Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis

AU - Foschi, Francesco Giuseppe

AU - Trevisani, Franco

AU - Loggi, Elisabetta

AU - Parazza, Monica

AU - Melotti, Cristina

AU - Bedeschi, Enrico

AU - Mingazzini, Lorenza

AU - Cappa, Federica Mirici

AU - Cescon, Matteo

AU - Andreone, Pietro

AU - Grazi, Gianluca

AU - Stefanini, Giuseppe Francesco

AU - Bernardi, Mauro

PY - 2005/7

Y1 - 2005/7

N2 - Background: Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function. Orthotopic liver transplantation (OLT) cures cirrhosis and might restore TA. This study was aimed at determining if OLT restores TA and PA. Methods: We measured in 9 cirrhotic patients, before and after successful OLT, TA by a bioassay and PA by chemiluminescence in which neutrophils of the patient were tested with both autologous (PA1) and pooled sera from healthy subjects (PA2). Splenic function was assayed by the pitted red cell count. Results: Before OLT, TA was reduced in 7 patients, and PA1 in all the patients. Pitted cell count was elevated in all the patients. After OLT (median 39 months; range 21-49), TA improved in all cases [median: from 8% (5-16%) to 20% (9-22%), p <0.008], normalizing in 5 out of the 7 patients with low values. PA1 improved in all the patients [from 102 cpm (65-128 cpm) to 235 cpm (78-280 cpm), p <0.008], normalizing in 5. Pitted red count decreased in 7 patients and normalized in 3 [from 3.3% (2.1-6.0%) to 2.4% (1.4-2.8%), p <0.021]. Platelet count [from 55 × 10 3 (30-100) to 185 × 10 3 (93-286), p <0.008] and leucocyte count [from 3.60 × 10 3 (1.81-5.23) to 5.53 × 10 3 (3.31-6.71), p <0.008] also improved. Conclusions: OLT improves TA and PA of cirrhotic patients. This effect is associated with an improvement of both functional hyposplenism and haematological hypersplenism. The restoration of natural defences against infections may mitigate the adverse effect of immunosuppressive treatment.

AB - Background: Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function. Orthotopic liver transplantation (OLT) cures cirrhosis and might restore TA. This study was aimed at determining if OLT restores TA and PA. Methods: We measured in 9 cirrhotic patients, before and after successful OLT, TA by a bioassay and PA by chemiluminescence in which neutrophils of the patient were tested with both autologous (PA1) and pooled sera from healthy subjects (PA2). Splenic function was assayed by the pitted red cell count. Results: Before OLT, TA was reduced in 7 patients, and PA1 in all the patients. Pitted cell count was elevated in all the patients. After OLT (median 39 months; range 21-49), TA improved in all cases [median: from 8% (5-16%) to 20% (9-22%), p <0.008], normalizing in 5 out of the 7 patients with low values. PA1 improved in all the patients [from 102 cpm (65-128 cpm) to 235 cpm (78-280 cpm), p <0.008], normalizing in 5. Pitted red count decreased in 7 patients and normalized in 3 [from 3.3% (2.1-6.0%) to 2.4% (1.4-2.8%), p <0.021]. Platelet count [from 55 × 10 3 (30-100) to 185 × 10 3 (93-286), p <0.008] and leucocyte count [from 3.60 × 10 3 (1.81-5.23) to 5.53 × 10 3 (3.31-6.71), p <0.008] also improved. Conclusions: OLT improves TA and PA of cirrhotic patients. This effect is associated with an improvement of both functional hyposplenism and haematological hypersplenism. The restoration of natural defences against infections may mitigate the adverse effect of immunosuppressive treatment.

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KW - Liver transplantation

KW - Phagocytic activity and neutrophil granulocytes

KW - Tuftsin

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